Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERBB4_HUMAN
Description:v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [Source:HGNC Symbol;Acc:3432]
Location:chr2 q34
Node attribute:kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y733AFGTVyKGIWVPkinase_TyrPhosphoSitePlus
Y1150LDEEGyMTPMRPhosphoSitePlus
Y1056SPPPAyTPMSGPhosphoSitePlus; HPRD; phosphoELM
Y1258LQHPDyLQEYSPhosphoSitePlus
Y1202KAEDEyVNEPLPhosphoSitePlus; HPRD
Y1268AENPEyLSEFSHPRD
Y1162KPKQEyLNPVEPhosphoSitePlus; HPRD
Y984RDPQRyLVIQGHPRD
Y1208VNEPLyLNTFAPhosphoSitePlus; HPRD
Y1035IPPPIyTSRARPhosphoSitePlus
Y1188LDNPEyHNASNPhosphoSitePlus; HPRD; phosphoELM
Y875GDEKEyNADGGPkinase_TyrPhosphoSitePlus
Y157NKFLCyADTIHHPRD
S183VSTNGsSGCGRHPRD
Y1242FDNPDyWNHSLPhosphoSitePlus; HPRD; phosphoELM
Y1284AENPEyLSEFSPhosphoSitePlus; HPRD; phosphoELM
Y1266EYSTKyFYKQNPhosphoSitePlus
Y733AFGTVyKGIWVHPRD; phosphoELM
Y1262DYLQEySTKYFPhosphoSitePlus
Y1022MDAEEyLVPQAHPRD
Y1221LGKAEyLKNNIPhosphoSitePlus; HPRD
Y1081GVSVPyRAPTSPhosphoSitePlus
T731SGAFGtVYKGIPkinase_TyrPhosphoSitePlus
Y1242LQHPDyLQEYSHPRD
S173RNPWPsNLTLVHPRD
Y1066GNQFVyRDGGFPhosphoSitePlus
Y1301LPPPPyRHRNTPhosphoSitePlus
Y1268STKYFyKQNGRPhosphoSitePlus; HPRD
S726VKVLGsGAFGTPkinase_TyrPhosphoSitePlus
Y1128SSTQRySADPTPhosphoSitePlus

Dephosphorylation site
ERBB4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385565K321NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000342235R306SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000403204C193*BIOMARTBreast Cancer21930507, 21930502
ENSP00000385565H295QBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235K935IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235V348LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235Y285CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000385565P1143HBIOMARTBreast Cancer21930507, 21930502
ENSP00000403204H295QBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235H295QBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235T244RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235H618PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235T140IGreenman2007Intestines Cancer17344846, 18428421
ENSP00000403204P1137HBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235T140IHPIColorectal Cancer17344846
ENSP00000403204K321NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385565C193*BIOMARTBreast Cancer21930507, 21930502
ENSP00000342235D931YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235S303YGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000342235N181SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000385565R701CBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235D595VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000342235K321NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000342235P1153HBIOMARTBreast Cancer21930507, 21930502
ENSP00000403204R711CBIOMARTBreast Cancer21930507, 21930502
ENSP00000342235C193*BIOMARTBreast Cancer21930507, 21930502
ENSP00000342235R711CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ERBB4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ERBB4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRG2_HUMANERBB4_HUMANligand -> receptorHPMR
BTC_HUMANERBB4_HUMANligand -> receptorHPMR
NRG3_HUMANERBB4_HUMANligand -> receptorHPMR
ERBB4_HUMANSTA5A_HUMANkinase -> substrateKEGG
BTC_HUMANERBB4_HUMANotherKEGG
NRG3_HUMANERBB4_HUMANotherKEGG
NRG1_HUMANERBB4_HUMANotherKEGG
NRG2_HUMANERBB4_HUMANotherKEGG
EREG_HUMANERBB4_HUMANotherKEGG
HBEGF_HUMANERBB4_HUMANotherKEGG
NRG4_HUMANERBB4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04012ErbB signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0021889olfactory bulb interneuron differentiationIEAbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007399nervous system developmentIEAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005759mitochondrial matrixTAScellular_component
GO:0007507heart developmentIEAbiological_process
GO:0007165signal transductionIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0061026cardiac muscle tissue regenerationIEAbiological_process
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitIEAmolecular_function
GO:0007595lactationIEAbiological_process
GO:0021551central nervous system morphogenesisIEAbiological_process
GO:0007399nervous system developmentISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIMPmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:2000366positive regulation of STAT protein import into nuIEAbiological_process
GO:0005154epidermal growth factor receptor bindingIPImolecular_function
GO:0001755neural crest cell migrationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0042803protein homodimerization activityIPImolecular_function
GO:0001934positive regulation of protein phosphorylationTASbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0060644mammary gland epithelial cell differentiationIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0006915apoptotic processIMPbiological_process
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0016020membraneIEAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0016477cell migrationIDAbiological_process
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0008283cell proliferationTASbiological_process