Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRG3_HUMAN
Description:neuregulin 3 [Source:HGNC Symbol;Acc:7999]
Location:chr10 q23.1
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S119FLSKPsSFPKAPhosphoSitePlus
T278KFHTTtYSTERPhosphoSitePlus
Y405QNGKSySLKASPhosphoSitePlus
T609VGLEEtCLQMPPhosphoSitePlus
Y357ESEEVyQRQVLNeuregulinPhosphoSitePlus
S116DPFFLsKPSSFPhosphoSitePlus
S255AASSSsSSSSSPhosphoSitePlus
S257SSSSSsSSSATPhosphoSitePlus
S254DAASSsSSSSSPhosphoSitePlus
S256ASSSSsSSSSAPhosphoSitePlus
T156PNRIStRLTTIPhosphoSitePlus
S410YSLKAsSTMAKPhosphoSitePlus

Dephosphorylation site
NRG3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361214G591ECOSMICSkin Cancer21984974
ENSP00000361214A164SCOSMICLung Cancer20668451
ENSP00000361214T276RCOSMICLung Cancer20668451
ENSP00000361214S238CCOSMICBreast Cancer20668451
ENSP00000361214W600SCOSMICLung Cancer20668451
ENSP00000361214L407PCOSMICHead and Neck Cancer21798893
ENSP00000361214A661VCOSMICLung Cancer20668451
ENSP00000361214V98MCOSMICHead and Neck Cancer21798893
ENSP00000361214D562HBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000361214R185WCOSMICLung Cancer20668451

Differential expressed protein
NRG3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NRG3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRG3_HUMANERBB4_HUMANligand -> receptorHPMR
NRG3_HUMANERBB4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneNAScellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0001558regulation of cell growthNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007171activation of transmembrane receptor protein tyrosNASbiological_process
GO:0008083growth factor activityNASmolecular_function
GO:0030297transmembrane receptor protein tyrosine kinase actNASmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0030971receptor tyrosine kinase bindingNASmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0060596mammary placode formationIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process


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