Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRG1_HUMAN
Description:neuregulin 1 [Source:HGNC Symbol;Acc:7997]
Location:chr8 p12
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S170TSSSTsTSTTGPhosphoSitePlus
Y424PHSERyVSAMTNeuregulinPhosphoSitePlus
T169NTSSStSTSTTPhosphoSitePlus
Y531ETTQEyEPAQENeuregulinPhosphoSitePlus
T528EEYETtQEYEPNeuregulinPhosphoSitePlus
Y525VEDEEyETTQENeuregulinPhosphoSitePlus
S435TPARMsPVDFHNeuregulinPhosphoSitePlus
T533EEYETtQEYEPHPRD
T528EEYETtQEYEPHPRD
T525EEYETtQEYEPHPRD

Dephosphorylation site
NRG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340497*248KCOSMICHead and Neck Cancer21798893
ENSP00000349275W360*COSMICSkin Cancer21984974
ENSP00000349275P599ACOSMICOvarian Cancer21720365
ENSP00000287840V481MBIOMARTchronic lymphocytic leukemia21930507, 21930502

Differential expressed protein
NRG1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NRG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRG1_HUMANERBB2_HUMANligand -> receptorHPMR
NRG1_HUMANERBB4_HUMANotherKEGG
NRG1_HUMANERBB3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008083growth factor activityNASmolecular_function
GO:0007626locomotory behaviorIEAbiological_process
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0055012ventricular cardiac muscle cell differentiationIDAbiological_process
GO:0007154cell communicationTASbiological_process
GO:0005176ErbB-2 class receptor bindingIEAmolecular_function
GO:0007399nervous system developmentIEAbiological_process
GO:0045785positive regulation of cell adhesionIDAbiological_process
GO:0045213neurotransmitter receptor metabolic processIEAbiological_process
GO:0046579positive regulation of Ras protein signal transducIEAbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisIDAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0055007cardiac muscle cell differentiationISSbiological_process
GO:0061098positive regulation of protein tyrosine kinase actIDAbiological_process
GO:0003712transcription cofactor activityIDAmolecular_function
GO:0043624cellular protein complex disassemblyIGIbiological_process
GO:0030879mammary gland developmentTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0016020membraneNAScellular_component
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007399nervous system developmentTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043497regulation of protein heterodimerization activityIDAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIDAbiological_process
GO:0014032neural crest cell developmentTASbiological_process
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0060956endocardial cell differentiationIDAbiological_process
GO:0051155positive regulation of striated muscle cell differISSbiological_process
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0043125ErbB-3 class receptor bindingIPImolecular_function
GO:0030297transmembrane receptor protein tyrosine kinase actNASmolecular_function
GO:0005102receptor bindingIPImolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0045202synapseIEAcellular_component
GO:0030296protein tyrosine kinase activator activityIDAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0051048negative regulation of secretionIDAbiological_process
GO:0042060wound healingTASbiological_process
GO:0007171activation of transmembrane receptor protein tyrosNASbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0038127ERBB signaling pathwayIDAbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0030971receptor tyrosine kinase bindingNASmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0003161cardiac conduction system developmentIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0043496regulation of protein homodimerization activityTASbiological_process
GO:0060379cardiac muscle cell myoblast differentiationIDAbiological_process
GO:0010667negative regulation of cardiac muscle cell apoptotIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0007416synapse assemblyIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIDAbiological_process
GO:0005125cytokine activityTASmolecular_function
GO:0042177negative regulation of protein catabolic processIEAbiological_process
GO:0016477cell migrationIEAbiological_process