| UniProt/SwissProt ID: | NRG2_HUMAN |
| Description: | neuregulin 2 [Source:HGNC Symbol;Acc:7998] |
| Location: | chr5 q31.2 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S30 | SSSSSsERSSS | PhosphoSitePlus | |
| S36 | ERSSSsSSSSS | PhosphoSitePlus | |
| S27 | YSDSSsSSSER | PhosphoSitePlus | |
| S767 | SLSLSsGSGGG | Neuregulin | PhosphoSitePlus |
| S37 | RSSSSsSSSSE | PhosphoSitePlus | |
| S582 | HDSVDsLRDSP | Neuregulin | PhosphoSitePlus |
| S35 | SERSSsSSSSS | PhosphoSitePlus | |
| S579 | PPYHDsVDSLR | Neuregulin | PhosphoSitePlus |
| S34 | SSERSsSSSSS | PhosphoSitePlus | |
| Y194 | ERNQRyIFFLE | PhosphoSitePlus | |
| S23 | RCSSYsDSSSS | PhosphoSitePlus | |
| S21 | KGRCSsYSDSS | PhosphoSitePlus | |
| S38 | SSSSSsSSSES | PhosphoSitePlus | |
| Dephosphorylation site |
| NRG2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354910 | R281Q | COSMIC | Breast Cancer | 20668451 | ENSP00000354910 | P394T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354910 | A398V | COSMIC | Melanoma | 21499247 | ENSP00000354910 | E566D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000354910 | K397E | COSMIC | Pancreatic Cancer | ENSP00000354910 | R323W | COSMIC | Pancreatic Cancer | ENSP00000354910 | R269C | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| NRG2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NRG2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRG2_HUMAN | ERBB3_HUMAN | ligand -> receptor | HPMR |
| NRG2_HUMAN | ERBB4_HUMAN | ligand -> receptor | HPMR |
| NRG2_HUMAN | ERBB3_HUMAN | other | KEGG |
| NRG2_HUMAN | ERBB4_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0009790 | embryo development | IEA | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |