Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRG2_HUMAN
Description:neuregulin 2 [Source:HGNC Symbol;Acc:7998]
Location:chr5 q31.2
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S30SSSSSsERSSSPhosphoSitePlus
S36ERSSSsSSSSSPhosphoSitePlus
S27YSDSSsSSSERPhosphoSitePlus
S767SLSLSsGSGGGNeuregulinPhosphoSitePlus
S37RSSSSsSSSSEPhosphoSitePlus
S582HDSVDsLRDSPNeuregulinPhosphoSitePlus
S35SERSSsSSSSSPhosphoSitePlus
S579PPYHDsVDSLRNeuregulinPhosphoSitePlus
S34SSERSsSSSSSPhosphoSitePlus
Y194ERNQRyIFFLEPhosphoSitePlus
S23RCSSYsDSSSSPhosphoSitePlus
S21KGRCSsYSDSSPhosphoSitePlus
S38SSSSSsSSSESPhosphoSitePlus

Dephosphorylation site
NRG2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354910R281QCOSMICBreast Cancer20668451
ENSP00000354910P394TCOSMICOvarian Cancer21720365
ENSP00000354910A398VCOSMICMelanoma21499247
ENSP00000354910E566DCOSMICHead and Neck Cancer21798893
ENSP00000354910K397ECOSMICPancreatic Cancer
ENSP00000354910R323WCOSMICPancreatic Cancer
ENSP00000354910R269CCOSMICBreast Cancer20668451

Differential expressed protein
NRG2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NRG2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRG2_HUMANERBB3_HUMANligand -> receptorHPMR
NRG2_HUMANERBB4_HUMANligand -> receptorHPMR
NRG2_HUMANERBB3_HUMANotherKEGG
NRG2_HUMANERBB4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionTAScellular_component
GO:0005102receptor bindingTASmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0009790embryo developmentIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function


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