Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHB3_HUMAN
Description:EPH receptor B3 [Source:HGNC Symbol;Acc:3394]
Location:chr3 q27.1
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y671TLKVGyTERQRPkinase_TyrPhosphoSitePlus
Y614IDPFTyEDPNEPhosphoSitePlus; SysPTM
T613YIDPFtYEDPNPhosphoSitePlus
S167PDESFsRLDAGEphrin_lbdPhosphoSitePlus
Y614IDPFTyEDPNEautocatalysis RegPhos; SysPTM
S413RRVHIsHLLAHfn3PhosphoSitePlus
Y600EKLQQyIAPGMPhosphoSitePlus; HPRD; phosphoELM
S901IRNAAsLKVIAPhosphoSitePlus
S201QGACMsLISVREphrin_lbdPhosphoSitePlus
Y812PEAIAyRKFTSPkinase_TyrPhosphoSitePlus
S795PTYTSsLGGKIPkinase_TyrPhosphoSitePlus
Y593GSDSEyTEKLQPhosphoSitePlus
S780SDFGLsRFLEDPkinase_TyrPhosphoSitePlus
Y792PSDPTyTSSLGHPRD
Y608PGMKVyIDPFTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T971LRIGVtLAGHQSAM_1PhosphoSitePlus
S768NILVNsNLVCKPkinase_TyrPhosphoSitePlus
T448AVNITtNQAAPPhosphoSitePlus
Y942IKMGRyKESFVautocatalysis RegPhos
Y792PSDPTyTSSLGautocatalysis RegPhos
Y608PGMKVyIDPFTautocatalysis RegPhos; SysPTM
S775LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
T731NDGQFtVIQLVPkinase_TyrPhosphoSitePlus
Y614IDPFTyEDPNEEphB3phosphoELM; RegPhos; SysPTM
T791DPSDPtYTSSLPkinase_TyrPhosphoSitePlus
Y614IDPFTyEDPNEEPHB3HPRD; SysPTM
S249NAVEVsVPLKLPhosphoSitePlus
T594SDSEYtEKLQQPhosphoSitePlus
Y924RTVPDyTTFTTSAM_1PhosphoSitePlus
Y792PSDPTyTSSLGPkinase_TyrPhosphoSitePlus
Y754LSEMNyVHRDLPkinase_TyrPhosphoSitePlus
S204CMSLIsVRAFYEphrin_lbdPhosphoSitePlus

Dephosphorylation site
EPHB3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332118L739FTCGAOvarian Cancer21720365, 18772890
ENSP00000332118R724WGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000332118R168LHPISmall cell lung carcinoma17344846
ENSP00000332118I560LTCGAOvarian Cancer21720365, 18772890
ENSP00000332118R168LGreenman2007Lung Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000332118Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueUp2.219329653
ENSP00000332118Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
EPHB3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB2_HUMANEPHB3_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB3_HUMANligand -> receptorHPMR
EFNB3_HUMANEPHB3_HUMANligand -> receptorHPMR
ZAP70_HUMANEPHB3_HUMANkinase -> substrateRobert H Newman (2013)
EPHB3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
EPHB3_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
EPHB3_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
EPHB3_HUMANEPHB3_HUMANkinase -> substrateHPRD
ZAGL2_HUMANEPHB3_HUMANkinase -> substrateRegPhos
EPHB3_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007413axonal fasciculationIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0051965positive regulation of synapse assemblyISSbiological_process
GO:0051965positive regulation of synapse assemblyIEAbiological_process
GO:0021952central nervous system projection neuron axonogeneIEAbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0060996dendritic spine developmentISSbiological_process
GO:0007413axonal fasciculationISSbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0022407regulation of cell-cell adhesionIDAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0022038corpus callosum developmentIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0032314regulation of Rac GTPase activityIDAbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0050770regulation of axonogenesisISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0060021palate developmentISSbiological_process
GO:0043088regulation of Cdc42 GTPase activityIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0005003ephrin receptor activityIDAmolecular_function
GO:0060996dendritic spine developmentIEAbiological_process
GO:0008046axon guidance receptor activityIEAmolecular_function
GO:0022038corpus callosum developmentISSbiological_process
GO:0048538thymus developmentISSbiological_process
GO:0001655urogenital system developmentISSbiological_process
GO:0001655urogenital system developmentIEAbiological_process
GO:0060997dendritic spine morphogenesisISSbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0050770regulation of axonogenesisIEAbiological_process
GO:0016477cell migrationIDAbiological_process
GO:0048546digestive tract morphogenesisISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0048538thymus developmentIEAbiological_process
GO:0060997dendritic spine morphogenesisIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0060021palate developmentIEAbiological_process


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