| UniProt/SwissProt ID: | EFNB2_HUMAN |
| Description: | ephrin-B2 [Source:HGNC Symbol;Acc:3227] |
| Location: | chr13 q33.3 |
| Node attribute: | ligand; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y311 | KVSGDyGHPVY | phosphoELM; RegPhos | |
| Y330 | SPANIyY | HPRD; phosphoELM; SysPTM | |
| Y304 | VFCPHyEKVSG | HPRD; RegPhos; SysPTM | |
| S308 | HYEKVsGDYGH | Shisa | PhosphoSitePlus |
| S325 | EMPPQsPANIY | HPRD; phosphoELM; SysPTM | |
| T274 | LSTLAtPKRSG | Shisa; UPF0560 | PhosphoSitePlus |
| Y304 | VFCPHyEKVSG | Shisa | PhosphoSitePlus; SysPTM |
| Y330 | SPANIyYKV__ | PhosphoSitePlus; SysPTM | |
| Y316 | YGHPVyIVQEM | phosphoELM; RegPhos | |
| Y331 | PANIYyKV___ | PhosphoSitePlus | |
| T69 | KVDSKtVGQYE | Ephrin | PhosphoSitePlus |
| Y316 | YGHPVyIVQEM | Shisa | PhosphoSitePlus |
| S325 | EMPPQsPANIY | Shisa | PhosphoSitePlus; SysPTM |
| Y330 | SPANIyYKV | RegPhos; SysPTM | |
| S260 | RHRKHsPQHTT | Shisa; Rifin_STEVOR; UPF0 | PhosphoSitePlus |
| S268 | HTTTLsLSTLA | Shisa; Rifin_STEVOR; UPF0 | PhosphoSitePlus |
| Y304 | VFCPHyEKVSG | EphB2 | phosphoELM; RegPhos; SysPTM |
| Y11 | DSVWKyCWGVL | PhosphoSitePlus | |
| Y311 | KVSGDyGHPVY | Shisa | PhosphoSitePlus |
| Dephosphorylation site |
| EFNB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000245323 | Q319* | COSMIC | Skin Cancer | 21984974 | ENSP00000245323 | P261L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| EFNB2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EFNB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EFNB2_HUMAN | EPHB4_HUMAN | ligand -> receptor | HPMR |
| EFNB2_HUMAN | EPHB3_HUMAN | ligand -> receptor | HPMR |
| EFNB2_HUMAN | EPHB2_HUMAN | ligand -> receptor | HPMR |
| EFNB2_HUMAN | EPHA4_HUMAN | ligand -> receptor | HPMR |
| EFNB2_HUMAN | EPHB1_HUMAN | ligand -> receptor | HPMR |
| ZAGL2_HUMAN | EFNB2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007155 | cell adhesion | IDA | biological_process |
| GO:0009887 | organ morphogenesis | IEA | biological_process |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0046875 | ephrin receptor binding | IPI | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:2000727 | positive regulation of cardiac muscle cell differe | ISS | biological_process |
| GO:0048013 | ephrin receptor signaling pathway | IDA | biological_process |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IDA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0050920 | regulation of chemotaxis | IDA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:2000727 | positive regulation of cardiac muscle cell differe | IEA | biological_process |
| GO:0001945 | lymph vessel development | IEA | biological_process |