| UniProt/SwissProt ID: | COT1_HUMAN |
| Description: | nuclear receptor subfamily 2, group F, member 1 [Source:HGNC Symbol;Acc:7975] |
| Location: | chr5 q15 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T200 | AEPYPtSRYGS | Hormone_recep | PhosphoSitePlus |
| Y355 | CALEEyVRSQY | Hormone_recep; XS | PhosphoSitePlus |
| T51 | SGAPHtPQTPG | PhosphoSitePlus | |
| T119 | VRRNLtYTCRA | zf-C4 | PhosphoSitePlus |
| T54 | PHTPQtPGQPG | PhosphoSitePlus | |
| T63 | PGAPAtPGTAG | PhosphoSitePlus | |
| Dephosphorylation site |
| COT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000325819 | V380G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000325819 | R194H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000325819 | N127S | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000325819 | V314I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000325819 | V380G | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| COT1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| COT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COT1_HUMAN | APOA1_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | APOC3_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | CP2D6_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | ANGT_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | APOA4_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | TRFE_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | EPO_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | FA9_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| COT1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043401 | steroid hormone mediated signaling pathway | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0030522 | intracellular receptor mediated signaling pathway | TAS | biological_process |
| GO:0043565 | sequence-specific DNA binding | IDA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0004879 | ligand-activated sequence-specific DNA binding RNA | IEA | molecular_function |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0003707 | steroid hormone receptor activity | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |