Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CNR1_HUMAN
Description:cannabinoid receptor 1 (brain) [Source:HGNC Symbol;Acc:2159]
Location:chr6 q15
Node attribute:GPCR; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S464VTMSVsTDTSAPhosphoSitePlus
Y215TAIDRyISIHR7tm_1PhosphoSitePlus
Y224HRPLAyKRIVT7tm_1PhosphoSitePlus
T465TMSVStDTSAEPhosphoSitePlus
T344IRLAKtLVLIL7tm_1; Flavi_NS4BPhosphoSitePlus
S429NSMGDsDCLHKPhosphoSitePlus
T460KIAKVtMSVSTPhosphoSitePlus
S425QPLDNsMGDSDPhosphoSitePlus

Dephosphorylation site
CNR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358511H302PCOSMICMelanoma21946352
ENSP00000358511R307CCOSMICMelanoma21946352
ENSP00000358511D10HCOSMICMelanoma21946352
ENSP00000358511P49SCOSMICMelanoma21946352
ENSP00000358511W255*COSMICMelanoma21946352
ENSP00000358511R220KCOSMICMelanoma21946352

Differential expressed protein
CNR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CNR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CNR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
CNR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CNR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CNR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
GLHA_HUMANCNR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04723Retrograde endocannabinoid signaling

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007610behaviorTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0042220response to cocaineIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0045759negative regulation of action potentialIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002866positive regulation of acute inflammatory responseIEAbiological_process
GO:0035094response to nicotineIEAbiological_process
GO:0060135maternal process involved in female pregnancyIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0031999negative regulation of fatty acid beta-oxidationIEAbiological_process
GO:0004949cannabinoid receptor activityIDAmolecular_function
GO:0033602negative regulation of dopamine secretionIEAbiological_process
GO:0032228regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0051001negative regulation of nitric-oxide synthase activIEAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0031622positive regulation of fever generationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0051966regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0060259regulation of feeding behaviorIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0060405regulation of penile erectionIEAbiological_process
GO:0033004negative regulation of mast cell activationIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIDAbiological_process
GO:0045777positive regulation of blood pressureIEAbiological_process
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0043271negative regulation of ion transportIEAbiological_process
GO:0007610behaviorIEAbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0004949cannabinoid receptor activityIEAmolecular_function
GO:0038171cannabinoid signaling pathwayIEAbiological_process
GO:0016021integral to membraneIEAcellular_component