| UniProt/SwissProt ID: | CD79A_HUMAN |
| Description: | CD79a molecule, immunoglobulin-associated alpha [Source:HGNC Symbol;Acc:1698] |
| Location: | chr19 q13.2 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y188 | EDENLyEGLNL | SRC_group | RegPhos |
| Y210 | GLQGTyQDVGS | Tyr-kinases | RegPhos |
| Y199 | DDCSMyEDISR | FYN | HPRD; RegPhos |
| Y188 | EDENLyEGLNL | LYN | HPRD; RegPhos |
| Y188 | EDENLyEGLNL | Lyn | phosphoELM; RegPhos |
| Y150 | EDENLyEGLNL | LYN | HPRD |
| Y188 | EDENLyEGLNL | ITAM | PhosphoSitePlus |
| S197 | NLDDCsMYEDI | ITAM | PhosphoSitePlus |
| Y182 | DAGDEyEDENL | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y199 | DDCSMyEDISR | Fyn | phosphoELM; RegPhos |
| Y161 | DDCSMyEDISR | FYN | HPRD |
| T140 | DMGEGtKNRII | PhosphoSitePlus | |
| Y199 | DDCSMyEDISR | ITAM | PhosphoSitePlus |
| Y210 | GLQGTyQDVGS | PhosphoSitePlus; phosphoELM; RegPhos | |
| T161 | AVVPGtLLLFR | TM | PhosphoSitePlus |
| Dephosphorylation site |
| CD79A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221972 | T161M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000221972 | T161M | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CD79A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD79A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | CD79A_HUMAN | kinase -> substrate | NetPath |
| LYN_HUMAN | CD79A_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos; NetPath; Robert H Newman (201 |
| FYN_HUMAN | CD79A_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | CD79A_HUMAN | kinase -> substrate | RegPhos |
| LCK_HUMAN | CD79A_HUMAN | kinase -> substrate | NetPath |
| PTN6_HUMAN | CD79A_HUMAN | phosphatase -> substrate | NetPath |
| COE1_HUMAN | CD79A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05340 | Primary immunodeficiency |
| hsa04662 | B cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0045121 | membrane raft | ISS | cellular_component |
| GO:0050853 | B cell receptor signaling pathway | ISS | biological_process |
| GO:0042113 | B cell activation | IEA | biological_process |
| GO:0019815 | B cell receptor complex | IEA | cellular_component |
| GO:0042100 | B cell proliferation | IEA | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0005771 | multivesicular body | ISS | cellular_component |
| GO:0009897 | external side of plasma membrane | ISS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0019815 | B cell receptor complex | ISS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0042100 | B cell proliferation | ISS | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IEA | biological_process |
| GO:0005771 | multivesicular body | IEA | cellular_component |
| GO:0042113 | B cell activation | ISS | biological_process |