| UniProt/SwissProt ID: | COE1_HUMAN |
| Description: | early B-cell factor 1 [Source:HGNC Symbol;Acc:3126] |
| Location: | chr5 q33.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y412 | IAEALySVPRN | PhosphoSitePlus | |
| Dephosphorylation site |
| COE1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000370029 | R129H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000322898 | A495T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000322898 | R129H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000322898 | R242Q | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| COE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| COE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COE1_HUMAN | CD79A_HUMAN | TF -> target gene | TRANSFAC |
| COE1_HUMAN | IGLL1_HUMAN | TF -> target gene | TRANSFAC |
| COE1_HUMAN | VPREB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| COE1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |