| UniProt/SwissProt ID: | CCR8_HUMAN |
| Description: | chemokine (C-C motif) receptor 8 [Source:HGNC Symbol;Acc:1609] |
| Location: | chr3 p22.2 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y132 | MSVDRyLAVVH | 7tm_1 | PhosphoSitePlus |
| S340 | CEKSSsCQQHS | PhosphoSitePlus | |
| S338 | ESCEKsSSCQQ | PhosphoSitePlus | |
| S339 | SCEKSsSCQQH | PhosphoSitePlus | |
| Dephosphorylation site |
| CCR8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000326432 | N232K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000326432 | I69N | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000326432 | N232K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000326432 | E333K | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| CCR8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CCR8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CCL1_HUMAN | CCR8_HUMAN | ligand -> receptor | HPMR |
| CCR8_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CCR8_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| CCR8_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CCR8_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CCL1_HUMAN | CCR8_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
| hsa05203 | Viral carcinogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004950 | chemokine receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006935 | chemotaxis | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0016493 | C-C chemokine receptor activity | IEA | molecular_function |
| GO:0015026 | coreceptor activity | TAS | molecular_function |