Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR3_HUMAN
Description:chemokine (C-C motif) receptor 3 [Source:HGNC Symbol;Acc:1604]
Location:chr3 p21.31
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
CCR3_HUMAN do not have phosphorylation site.

Dephosphorylation site
CCR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379273N297HCOSMICBreast Cancer20668451
ENSP00000350003N297HCOSMICBreast Cancer20668451
ENSP00000440097M283LCOSMICLung Cancer20668451
ENSP00000440097M296ICOSMICRenal Cancer20054297
ENSP00000440097F316SCOSMICOvarian Cancer21720365
ENSP00000379271F316SCOSMICOvarian Cancer21720365
ENSP00000440097T181NCOSMICLung Cancer20668451
ENSP00000379271M296ICOSMICRenal Cancer20054297
ENSP00000379273M283LCOSMICLung Cancer20668451
ENSP00000379271T181NCOSMICLung Cancer20668451
ENSP00000379273V56LCOSMICOvarian Cancer21720365
ENSP00000440097V56LCOSMICOvarian Cancer21720365
ENSP00000350003M283LCOSMICLung Cancer20668451
ENSP00000350003T181NCOSMICLung Cancer20668451
ENSP00000379273L331FCOSMICOvarian Cancer20668451
ENSP00000350003M296ICOSMICRenal Cancer20054297
ENSP00000440097L331FCOSMICOvarian Cancer20668451
ENSP00000379273F316SCOSMICOvarian Cancer21720365
ENSP00000379271N297HCOSMICBreast Cancer20668451
ENSP00000379271V56LCOSMICOvarian Cancer21720365
ENSP00000379271L331FCOSMICOvarian Cancer20668451
ENSP00000440097N297HCOSMICBreast Cancer20668451
ENSP00000350003F316SCOSMICOvarian Cancer21720365
ENSP00000379273T181NCOSMICLung Cancer20668451
ENSP00000379273M296ICOSMICRenal Cancer20054297
ENSP00000350003V56LCOSMICOvarian Cancer21720365
ENSP00000350003L331FCOSMICOvarian Cancer20668451
ENSP00000379271M283LCOSMICLung Cancer20668451

Differential expressed protein
CCR3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL8_HUMANCCR3_HUMANligand -> receptorHPMR
CCL13_HUMANCCR3_HUMANligand -> receptorHPMR
CCL28_HUMANCCR3_HUMANligand -> receptorHPMR
CCL24_HUMANCCR3_HUMANligand -> receptorHPMR
CCL5_HUMANCCR3_HUMANligand -> receptorHPMR
CCL7_HUMANCCR3_HUMANligand -> receptorHPMR
CCL26_HUMANCCR3_HUMANligand -> receptorHPMR
CCL15_HUMANCCR3_HUMANligand -> receptorHPMR
CCL11_HUMANCCR3_HUMANligand -> receptorHPMR
CCR3_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CCR3_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CCR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR3_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CCL28_HUMANCCR3_HUMANotherKEGG
CCL13_HUMANCCR3_HUMANotherKEGG
CCL5_HUMANCCR3_HUMANotherKEGG
CCL24_HUMANCCR3_HUMANotherKEGG
CCL11_HUMANCCR3_HUMANotherKEGG
CCL8_HUMANCCR3_HUMANotherKEGG
CCL15_HUMANCCR3_HUMANotherKEGG
CCL26_HUMANCCR3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035476angioblast cell migrationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0048245eosinophil chemotaxisIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0006968cellular defense responseTASbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0002551mast cell chemotaxisIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0070098chemokine-mediated signaling pathwayTASbiological_process
GO:0004950chemokine receptor activityTASmolecular_function
GO:0016493C-C chemokine receptor activityIEAmolecular_function


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