Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:C2TA_HUMAN
Description:class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:7067]
Location:chr16 p13.13
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S834LPGRLsFLGTRPRKACAHPRD
S1050SLLRLsLYNNCPKACaRegPhos
S288RPGSTsPFAPSPhosphoSitePlus
S1050SLLRLsLYNNCPKA_groupphosphoELM; RegPhos
S427AGQGKsYWAGANACHTPhosphoSitePlus
S834LPGRLsFLGTRPKA_groupphosphoELM; RegPhos
S1050SLLRLsLYNNCPhosphoSitePlus
S834LPGRLsFLGTRPKACaRegPhos
S834LPGRLsFLGTRPhosphoSitePlus
S286PDRPGsTSPFAPhosphoSitePlus
T947SSSEDtAGELPPhosphoSitePlus
S280HGLPTsPDRPGPhosphoSitePlus
S1050SLLRLsLYNNCPRKACAHPRD
S1073LPDMVsLRVMDPhosphoSitePlus
S373ARLERsSSKSLPhosphoSitePlus
T546CTLLLtARPRGNACHTPhosphoSitePlus
S293SPFAPsATDLPPhosphoSitePlus
Y428GQGKSyWAGAVNACHTPhosphoSitePlus
S434WAGAVsRAWACNACHTPhosphoSitePlus

Dephosphorylation site
C2TA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316328E89*COSMICSkin Cancer21984974
ENSP00000316328A691DTCGAOvarian Cancer21720365, 18772890
ENSP00000316328A691DCOSMICOvarian Cancer21720365

Differential expressed protein
C2TA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
C2TA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANC2TA_HUMANkinase -> substrateHPRD
ATF1_HUMANC2TA_HUMANTF -> target geneTRANSFAC
USF1_HUMANC2TA_HUMANTF -> target geneTRANSFAC
PRDM1_HUMANC2TA_HUMANTF -> target geneTRANSFAC
IRF1_HUMANC2TA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05340Primary immunodeficiency
hsa05164Influenza A
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa04612Antigen processing and presentation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0006955immune responseTASbiological_process
GO:0045348positive regulation of MHC class II biosynthetic pICbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045345positive regulation of MHC class I biosynthetic prIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0032966negative regulation of collagen biosynthetic proceICbiological_process
GO:0046677response to antibioticIDAbiological_process
GO:0032403protein complex bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0034341response to interferon-gammaIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process


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