Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BRAF_HUMAN
Description:v-raf murine sarcoma viral oncogene homolog B1 [Source:HGNC Symbol;Acc:1097]
Location:chr7 q34
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S446LGRRDsSDDWEPAK1phosphoELM
S446LGRRDsSDDWEPhosphoSitePlus; HPRD; phosphoELM
S335ILTSPsPSKSIHPRD; phosphoELM
S151RSNPKsPQKPIPhosphoSitePlus; phosphoELM
S430ERKSSsSSEDRPRKACAHPRD
S430ERKSSsSSEDRPhosphoSitePlus
S579HRDLKsNNIFLphosphoELM
S365RDRSSsAPNVHPhosphoSitePlus; phosphoELM
Y760IQAGGyGAFPVPhosphoSitePlus
T599DFGLAtVKSRWPkinase_TyrPhosphoSitePlus
S750LYACAsPKTPIBRAFHPRD
S429RERKSsSSSEDPKB_groupphosphoELM
T599DFGLAtVKSRWHPRD; phosphoELM
S365RDRSSsAPNVHSGK1HPRD
S319SGSSPsAPASDHPRD; phosphoELM
S151RSNPKsPQKPIBRAFHPRD
S727PKIHRsASEPSphosphoELM
S399STTGLsATPPAPhosphoSitePlus; phosphoELM
S429RERKSsSSSEDAKT1HPRD
S365RDRSSsAPNVHSGK_groupphosphoELM
T119SASMDtVTSSSPhosphoSitePlus; HPRD
S605VKSRWsGSHQFPkinase_TyrPhosphoSitePlus
S429RERKSsSSSEDPhosphoSitePlus
Y746EDFSLyACASPPhosphoSitePlus
S732SASEPsLNRAGPhosphoSitePlus
S429RERKSsSSSEDPKA_groupphosphoELM
S365RDRSSsAPNVHAKT1HPRD
S428QRERKsSSSSEPhosphoSitePlus
S446LGRRDsSDDWERHEBHPRD
S579HRDLKsNNIFLPkinase_TyrPhosphoSitePlus
S602LATVKsRWSGSPkinase_TyrPhosphoSitePlus
S447GRRDSsDDWEIPhosphoSitePlus; HPRD; phosphoELM
T753CASPKtPIQAGPhosphoSitePlus
S333PQILTsPSPSKPhosphoSitePlus; HPRD; phosphoELM
S364QRDRSsSAPNVPhosphoSitePlus; HPRD; phosphoELM
T373NVHINtIEPVNBRAFHPRD
T244RKTFFtLAFCDC1_1PhosphoSitePlus
S729IHRSAsEPSLNPhosphoSitePlus; HPRD; phosphoELM
T401TGLSAtPPASLPhosphoSitePlus; HPRD; phosphoELM
S363GQRDRsSSAPNPhosphoSitePlus; HPRD
T470SGSFGtVYKGKPkinase_TyrPhosphoSitePlus
S419KALQKsPGPQRPhosphoSitePlus; phosphoELM
S419KALQKsPGPQRBRAFHPRD
Y85EAYEEyTSKLDPhosphoSitePlus
S147TDVARsNPKSPPhosphoSitePlus
S750LYACAsPKTPIPhosphoSitePlus; phosphoELM
T440RNRMKtLGRRDPhosphoSitePlus; HPRD; phosphoELM
S602LATVKsRWSGSHPRD; phosphoELM
Y566AQGMDyLHAKSPkinase_TyrPhosphoSitePlus
S147TDVARsNPKSPBRAFHPRD
S465GQRIGsGSFGTPkinase_TyrPhosphoSitePlus
S365RDRSSsAPNVHPKB_groupphosphoELM
S614QFEQLsGSILWPkinase_TyrPhosphoSitePlus
T373NVHINtIEPVNPhosphoSitePlus; phosphoELM
S432KSSSSsEDRNRPhosphoSitePlus

Dephosphorylation site
BRAF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000288602G469VBIOMARTLung Cancer21930507, 21930502
ENSP00000288602G464EOMIMColorectal Cancer12198537 12960123
ENSP00000288602N581SGreenman2007Intestines Cancer12438234, 17344846, 18428421, 18451217
ENSP00000288602D594GOMIM, HPILymphoma14612909 12960123, 14612909 22001634 21483012 20496269 19269016 18794803 15948220 14534542 14500346
ENSP00000288602L597RGreenman2007Ovarian Cancer12068308, 12460919, 17344846, 18368129, 18428421
ENSP00000288602G466VOMIM, HPILung Cancer12460919 12960123, 12460919 12068308 17409805
ENSP00000288602E586KHPIOvarian Cancer12068308 17195637 15577314 15456136
ENSP00000288602G596RHPIColorectal Cancer12068308 17344846 20496269 19735675 14678966
ENSP00000288602L597RGreenman2007Neoplasms by Histologic Type12068308, 12460919, 17344846, 18368129, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Other Cancer(ns cancer, adrenal_gland cancer, eye cancer)12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600ESjoblom2006, Greenman2007Pituitary Carcinoma12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600ESjoblom2006, Greenman2007Liver Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602L597VOMIMNon-small cell lung carcinoma12460918 12960123
ENSP00000288602L597VGreenman2007Uterine Cancer12068308, 12460918, 12692057, 15048078, 16140923, 17344846, 17360030, 18397470, 18428421
ENSP00000288602K601EOMIM, HPIColorectal Cancer12198537 12960123 16187918, 12198537 22133769 22136270 20718682 20186005 18697864 18329792 17956956 17785355 17824790 17721188 16219715 16187918 16021577 15902486 14743508 15095090 14695152 14668801 14678966 12881714
ENSP00000288602V600ESjoblom2006, Greenman2007Gastric Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602R462IOMIM, HPIColorectal Cancer12198537 12960123, 12198537 15150094
ENSP00000288602G469VDing2008, Greenman2007Lung Cancer12692057, 12879021, 14724583, 15729718, 15948115, 17344846, 18428421, 18451217, 18948947
ENSP00000288602L597RHPILung Cancer12460919 12068308 17344846
ENSP00000288602V600EOMIMMelanoma12960123 12068308 12447372 12619120 12794760 14513361 12198537 12644542 20818844 20823850 21107320 21107323 22113612 15342696 16015629 19571295 12670889 15001635 14602780 15356022 15126572 15181070 16174717 15687339 15998781 16187918 17374713 16772349 17488796 17785355 15386408 18398503
ENSP00000288602L597RGreenman2007Skin Cancer12068308, 12460919, 17344846, 18368129, 18428421
ENSP00000288602V600ESjoblom2006, OMIM, Greenman2007Neoplasms by Histologic Type12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079, 21930507, 21930502, 12068308, 12198537, 14500344, 16959974, 17344846, 22313586, 22319199, 22317887, 22314188, 22260668, 22306669, 22293660, 22278153, 22274583, 22261672, 22250191, 22241789, 22234612, 22230299, 22227015, 22235286, 22210186, 22192803, 22212971, 21358618, 12960123, 12068308, 12447372, 12619120, 12794760, 14513361, 12198537, 12644542, 20818844, 20823850, 21107320, 21107323, 22113612, 15342696, 16015629, 19571295, 12670889, 15001635, 14602780, 15356022, 15126572, 15181070, 16174717, 15687339, 15998781, 16187918, 17374713, 16772349, 17488796, 17785355, 15386408, 18398503, 12960123 12068308 12447372 12619120 12794760 14513361 12198537 12644542 20818844 20823850 21107320 21107323 22113612 15342696 16015629 19571295 12670889 15001635 14602780 15356022 15126572 15181070 16174717 15687339 15998781 16187918 17374713 16772349 17488796 17785355 15386408 18398503
ENSP00000288602N581SHPIColorectal Cancer17344846
ENSP00000288602G421VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000288602G469VDing2008, Greenman2007Head and Neck Cancer12692057, 12879021, 14724583, 15729718, 15948115, 17344846, 18428421, 18451217, 18948947
ENSP00000288602G469AGreenman2007Neoplasms by Histologic Type12068308, 12941809, 14603338, 14612909, 15194222, 16140923, 17344846, 18428421
ENSP00000288602L597VGreenman2007Biliary Tract Cancer12068308, 12460918, 12692057, 15048078, 16140923, 17344846, 17360030, 18397470, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Ovarian Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600EBIOMART, OMIMColorectal Cancer21930507, 21930502, 12960123 12068308 12447372 12619120 12794760 14513361 12198537 12644542 20818844 20823850 21107320 21107323 22113612 15342696 16015629 19571295 12670889 15001635 14602780 15356022 15126572 15181070 16174717 15687339 15998781 16187918 17374713 16772349 17488796 17785355 15386408 18398503
ENSP00000288602K601EOMIMThyroid Carcinoma12198537 12960123 16187918
ENSP00000288602V600ESjoblom2006, Greenman2007Skin Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600EHPISarcoma12068308 12198537 14500344 16959974 17344846 22313586 22319199 22317887 22314188 22260668 22306669 22293660 22278153 22274583 22261672 22250191 22241789 22234612 22230299 22227015 22235286 22210186 22192803 22212971 21358618
ENSP00000288602V600ESjoblom2006, OMIM, Greenman2007Thyroid Carcinoma12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079, 12960123 12068308 12447372 12619120 12794760 14513361 12198537 12644542 20818844 20823850 21107320 21107323 22113612 15342696 16015629 19571295 12670889 15001635 14602780 15356022 15126572 15181070 16174717 15687339 15998781 16187918 17374713 16772349 17488796 17785355 15386408 18398503
ENSP00000288602G469AOMIMLymphoma14612909 12960123
ENSP00000288602G464VHPIColorectal Cancer12068308 14734469
ENSP00000288602T310IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000288602L597RGreenman2007Lung Cancer12068308, 12460919, 17344846, 18368129, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Breast Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602Q636EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000288602I463SOMIM, HPIColorectal Cancer12198537 12960123, 12198537 15150094
ENSP00000288602G469VDing2008, Greenman2007Biliary Tract Cancer12692057, 12879021, 14724583, 15729718, 15948115, 17344846, 18428421, 18451217, 18948947
ENSP00000288602V600ESjoblom2006, Greenman2007Lung Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600ESjoblom2006, Greenman2007Pancreatic Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602G469VHPIColorectal Cancer17344846
ENSP00000288602G469AGreenman2007Lung Cancer12068308, 12941809, 14603338, 14612909, 15194222, 16140923, 17344846, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Central Nervous System Neoplasms12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602V600ESjoblom2006, Greenman2007Biliary Tract Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602G469VDing2008, Greenman2007Skin Cancer12692057, 12879021, 14724583, 15729718, 15948115, 17344846, 18428421, 18451217, 18948947
ENSP00000288602F595LHPIColorectal Cancer12068308 16439621 18042262 19206169 14678966
ENSP00000288602G469AGreenman2007Intestines Cancer12068308, 12941809, 14603338, 14612909, 15194222, 16140923, 17344846, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Head and Neck Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079
ENSP00000288602G469VDing2008, Greenman2007Intestines Cancer12692057, 12879021, 14724583, 15729718, 15948115, 17344846, 18428421, 18451217, 18948947
ENSP00000288602V600ESjoblom2006, Greenman2007Intestines Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079, 21930507, 21930502, 12068308, 12198537, 14500344, 16959974, 17344846, 22313586, 22319199, 22317887, 22314188, 22260668, 22306669, 22293660, 22278153, 22274583, 22261672, 22250191, 22241789, 22234612, 22230299, 22227015, 22235286, 22210186, 22192803, 22212971, 21358618, 12960123, 12068308, 12447372, 12619120, 12794760, 14513361, 12198537, 12644542, 20818844, 20823850, 21107320, 21107323, 22113612, 15342696, 16015629, 19571295, 12670889, 15001635, 14602780, 15356022, 15126572, 15181070, 16174717, 15687339, 15998781, 16187918, 17374713, 16772349, 17488796, 17785355, 15386408, 18398503
ENSP00000288602G596RGreenman2007Intestines Cancer12068308, 12438234, 17344846, 18428421, 12068308, 17344846, 20496269, 19735675, 14678966
ENSP00000288602R671QBIOMARTBreast Cancer21930507, 21930502
ENSP00000288602L597VGreenman2007Lung Cancer12068308, 12460918, 12692057, 15048078, 16140923, 17344846, 17360030, 18397470, 18428421
ENSP00000288602L597VGreenman2007Skin Cancer12068308, 12460918, 12692057, 15048078, 16140923, 17344846, 17360030, 18397470, 18428421
ENSP00000288602V600ESjoblom2006, Greenman2007Prostate Cancer12068308, 12198537, 12438234, 12447372, 12460918, 12591721, 12619120, 12644542, 12670889, 12692057, 12697856, 12778069, 12794760, 12819038, 12873977, 12873990, 12879021, 12881714, 12907632, 12941809, 12960123, 12969789, 12970315, 14500344, 14500346, 14501284, 14507635, 14508525, 14513361, 14522889, 14522897, 14602780, 14616967, 14639609, 14668801, 14679157, 14681681, 14688025, 14691295, 14695143, 14695152, 14695993, 14708620, 14722037, 14724583, 14734469, 14961576, 14984580, 14991899, 14996715, 14996725, 15001635, 15009714, 15009715, 15014028, 15046639, 15048078, 15095090, 15102681, 15104286, 15126572, 15140228, 15140238, 15145515, 15145934, 15161700, 15179189, 15181070, 15184373, 15191558, 15194222, 15195111, 15195137, 15221372, 15247181, 15251969, 15272920, 15273715, 15277467, 15294323, 15331929, 15340260, 15342696, 15356020, 15356022, 15373778, 15466181, 15467732, 15472223, 15482489, 15515191, 15517309, 15542810, 15547711, 15588860, 15616773, 15630448, 15641040, 15671769, 15687339, 15688405, 15702478, 15714593, 15729718, 15735849, 15737846, 15765445, 15781657, 15790700, 15791479, 15807885, 15841378, 15880523, 15917418, 15928660, 15935100, 15947103, 15948115, 15948220, 15968271, 15980887, 15991007, 15998781, 16001072, 16007166, 16007203, 16015629, 16096377, 16098042, 16117801, 16123397, 16143028, 16143123, 16166444, 16170021, 16174717, 16179870, 16231316, 16281072, 16376942, 16381005, 16403224, 16404419, 16410717, 16421887, 16452550, 16487015, 16540682, 16601293, 16676402, 16721043, 16721785, 16728573, 16728576, 16753739, 16772349, 16773193, 16786134, 16804544, 16818621, 16858683, 16879389, 16896265, 16918136, 16931592, 16932068, 16937524, 16959974, 16987295, 17011185, 17054470, 17060774, 17065421, 17087942, 17096315, 17096326, 17119056, 17119447, 17134824, 17143260, 17143472, 17159251, 17159915, 17186541, 17199440, 17199737, 17273161, 17308088, 17308360, 17315191, 17318013, 17344846, 17363500, 17374713, 17404088, 17440063, 17453004, 17465858, 17478764, 17488796, 17518771, 17535228, 17638058, 17725429, 17785355, 17786355, 17923875, 18000091, 18060073, 18068703, 18199160, 18217967, 18227705, 18300810, 18310286, 18329792, 18363883, 18368129, 18375819, 18382358, 18383861, 18393366, 18397470, 18398503, 18403637, 18408659, 18428050, 18428421, 18451217, 18462259, 18470905, 18509361, 18575712, 18592002, 18615679, 18619647, 18636014, 18682506, 18753363, 18945298, 19016743, 19147753, 19190079

Differential expressed protein
BRAF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BRAF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RHEB_HUMANBRAF_HUMANkinase -> substrateHPRD
AKT1_HUMANBRAF_HUMANkinase -> substrateRegPhos
BRAF_HUMANMP2K1_HUMANkinase -> substrateRegPhos
PKN1_HUMANBRAF_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SGK1_HUMANBRAF_HUMANkinase -> substrateHPRD; RegPhos
MK01_HUMANBRAF_HUMANkinase -> substrateNetPath
KPCA_HUMANBRAF_HUMANkinase -> substrateHPRD
BRAF_HUMANMP2K2_HUMANkinase -> substrateKEGG
BRAF_HUMANBRAF_HUMANkinase -> substrateHPRD
ZAGL2_HUMANBRAF_HUMANkinase -> substrateRegPhos
RAP1A_HUMANBRAF_HUMANotherKEGG
RHEB_HUMANBRAF_HUMANotherKEGG
RRAS2_HUMANBRAF_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04730Long-term depression
hsa05221Acute myeloid leukemia
hsa05212Pancreatic cancer
hsa05034Alcoholism
hsa04810Regulation of actin cytoskeleton
hsa04726Serotonergic synapse
hsa04150mTOR signaling pathway
hsa05160Hepatitis C
hsa05220Chronic myeloid leukemia
hsa04010MAPK signaling pathway
hsa05218Melanoma
hsa04270Vascular smooth muscle contraction
hsa04914Progesterone-mediated oocyte maturation
hsa05216Thyroid cancer
hsa04510Focal adhesion
hsa05210Colorectal cancer
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04720Long-term potentiation
hsa04062Chemokine signaling pathway
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05200Pathways in cancer
hsa05219Bladder cancer
hsa05215Prostate cancer
hsa05214Glioma
hsa04722Neurotrophin signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05223Non-small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000186activation of MAPKK activityTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0009887organ morphogenesisTASbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0070849response to epidermal growth factor stimulusIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0071277cellular response to calcium ionIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070849response to epidermal growth factor stimulusIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function