Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	BAX_HUMAN
Description:	BCL2-associated X protein [Source:HGNC Symbol;Acc:959]
Location:	chr19 q13.33
Node attribute:	PPI(source); substrate; gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S87	AVDTDsPREVF		HPRD
S60	STKKLsECLKR		PhosphoSitePlus
T167	LSYFGtPTWQT		PhosphoSitePlus
S38	AVDTDsPREVF		HPRD
S184	GVLTAsLTIWK	TM	PhosphoSitePlus
S184	GVLTAsLTIWK		phosphoELM
T140	TIMGWtLDFLR	Bcl-2	PhosphoSitePlus
S87	AVDTDsPREVF	Bcl-2	PhosphoSitePlus
T135	PELIRtIMGWT	Bcl-2	PhosphoSitePlus
S163	WDGLLsYFGTP		PhosphoSitePlus

Dephosphorylation site

BAX_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000293288	R94*	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000263262	G108V	HPI	Lymphoma	7475270 9531611
ENSP00000263262	G67R	HPI	acute lymphocytic leukemia	7475270 9531611
ENSP00000263262	G67R	OMIM	Leukemia	9531611
ENSP00000293288	G10D	COSMIC	Central Nervous System Neoplasms	18772890

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000263262	Hepatocellular Carcinoma	Normal vs. Cancer	cell line	Up	2.3	18646787
ENSP00000263262	Hepatocellular Carcinoma	Normal vs. Cancer	cell line	Up	2.4	18646787
ENSP00000263262	Lung Cancer	Normal vs. Cancer	tissue	Up		12943690
ENSP00000263262	Lung Cancer	Normal vs. Cancer	tissue	Up		15626334

Hyperphosphorylation site

BAX_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
DYRK2_HUMAN	BAX_HUMAN	kinase -> substrate	Robert H Newman (2013)
BLK_HUMAN	BAX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TNI3K_HUMAN	BAX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6B1_HUMAN	BAX_HUMAN	kinase -> substrate	Robert H Newman (2013)
BAX_HUMAN	CYC_HUMAN	other	KEGG
BAX_HUMAN	BCL2_HUMAN	other	KEGG
P53_HUMAN	BAX_HUMAN	TF -> target gene	KEGG
P53_HUMAN	BAX_HUMAN	TF -> target gene	TRANSFAC
P73_HUMAN	BAX_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	BAX_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05020	Prion diseases
hsa05210	Colorectal cancer
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05200	Pathways in cancer
hsa05016	Huntington's disease
hsa04141	Protein processing in endoplasmic reticulum
hsa05152	Tuberculosis
hsa04210	Apoptosis
hsa05166	HTLV-I infection
hsa04722	Neurotrophin signaling pathway
hsa05203	Viral carcinogenesis
hsa04115	p53 signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0001836	release of cytochrome c from mitochondria	IEA	biological_process
GO:0001541	ovarian follicle development	IEA	biological_process
GO:0008635	activation of cysteine-type endopeptidase activity	IDA	biological_process
GO:0043065	positive regulation of apoptotic process	IMP	biological_process
GO:0097193	intrinsic apoptotic signaling pathway	IDA	biological_process
GO:0001777	T cell homeostatic proliferation	IEA	biological_process
GO:0051402	neuron apoptotic process	IEA	biological_process
GO:0097190	apoptotic signaling pathway	IDA	biological_process
GO:0006915	apoptotic process	IDA	biological_process
GO:0048147	negative regulation of fibroblast proliferation	IEA	biological_process
GO:0043496	regulation of protein homodimerization activity	IDA	biological_process
GO:0001101	response to acid	IEA	biological_process
GO:0043525	positive regulation of neuron apoptotic process	IDA	biological_process
GO:0001764	neuron migration	IEA	biological_process
GO:0048515	spermatid differentiation	IEA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0032471	reduction of endoplasmic reticulum calcium ion con	IEA	biological_process
GO:0005783	endoplasmic reticulum	IDA	cellular_component
GO:0006974	response to DNA damage stimulus	IEA	biological_process
GO:0043065	positive regulation of apoptotic process	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0006915	apoptotic process	IEA	biological_process
GO:0051260	protein homooligomerization	IEA	biological_process
GO:0051259	protein oligomerization	IDA	biological_process
GO:0010248	establishment or maintenance of transmembrane elec	IDA	biological_process
GO:0048678	response to axon injury	IEA	biological_process
GO:0006917	induction of apoptosis	IEA	biological_process
GO:0043653	mitochondrial fragmentation involved in apoptotic	IDA	biological_process
GO:0007399	nervous system development	IEA	biological_process
GO:0051881	regulation of mitochondrial membrane potential	IDA	biological_process
GO:0060058	positive regulation of apoptotic process involved	IEA	biological_process
GO:0032461	positive regulation of protein oligomerization	IDA	biological_process
GO:0005741	mitochondrial outer membrane	TAS	cellular_component
GO:0060011	Sertoli cell proliferation	IEA	biological_process
GO:0051281	positive regulation of release of sequestered calc	IEA	biological_process
GO:0009636	response to toxin	IEA	biological_process
GO:0071310	cellular response to organic substance	IEA	biological_process
GO:0009651	response to salt stress	IEA	biological_process
GO:0008637	apoptotic mitochondrial changes	IDA	biological_process
GO:0030264	nuclear fragmentation involved in apoptotic nuclea	IMP	biological_process
GO:0031966	mitochondrial membrane	IEA	cellular_component
GO:0001844	protein insertion into mitochondrial membrane invo	IEA	biological_process
GO:0006919	activation of cysteine-type endopeptidase activity	IMP	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0007281	germ cell development	IEA	biological_process
GO:0035234	germ cell programmed cell death	IEA	biological_process
GO:0008283	cell proliferation	IEA	biological_process
GO:0002352	B cell negative selection	IEA	biological_process
GO:0090200	positive regulation of release of cytochrome c fro	IDA	biological_process
GO:0008637	apoptotic mitochondrial changes	IEA	biological_process
GO:2001244	positive regulation of intrinsic apoptotic signali	IMP	biological_process
GO:0006808	regulation of nitrogen utilization	IEA	biological_process
GO:0030264	nuclear fragmentation involved in apoptotic nuclea	IEA	biological_process
GO:0008635	activation of cysteine-type endopeptidase activity	IEA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0046982	protein heterodimerization activity	IEA	molecular_function
GO:0044445	cytosolic part	IEA	cellular_component
GO:0021987	cerebral cortex development	IEA	biological_process
GO:0007548	sex differentiation	IEA	biological_process
GO:0005741	mitochondrial outer membrane	IEA	cellular_component
GO:0046982	protein heterodimerization activity	IPI	molecular_function
GO:0009791	post-embryonic development	IEA	biological_process
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0001776	leukocyte homeostasis	IEA	biological_process
GO:0048597	post-embryonic camera-type eye morphogenesis	IEA	biological_process
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0051434	BH3 domain binding	IPI	molecular_function
GO:0048872	homeostasis of number of cells	IEA	biological_process
GO:0009566	fertilization	IEA	biological_process
GO:0008285	negative regulation of cell proliferation	IEA	biological_process
GO:0001836	release of cytochrome c from mitochondria	IDA	biological_process
GO:0005789	endoplasmic reticulum membrane	IDA	cellular_component
GO:1900103	positive regulation of endoplasmic reticulum unfol	IMP	biological_process
GO:0033137	negative regulation of peptidyl-serine phosphoryla	IEA	biological_process
GO:0032976	release of matrix enzymes from mitochondria	IDA	biological_process
GO:0008584	male gonad development	IEA	biological_process
GO:0032091	negative regulation of protein binding	IDA	biological_process
GO:0002262	myeloid cell homeostasis	IEA	biological_process
GO:0001974	blood vessel remodeling	IEA	biological_process
GO:0060068	vagina development	IEA	biological_process
GO:0019048	virus-host interaction	IEA	biological_process
GO:0015267	channel activity	IDA	molecular_function
GO:0005634	nucleus	IMP	cellular_component
GO:0006927	transformed cell apoptotic process	IMP	biological_process
GO:0005622	intracellular	IEA	cellular_component
GO:0010212	response to ionizing radiation	IEA	biological_process
GO:0006309	apoptotic DNA fragmentation	IMP	biological_process
GO:0006687	glycosphingolipid metabolic process	IEA	biological_process
GO:0042803	protein homodimerization activity	IEA	molecular_function
GO:0051434	BH3 domain binding	IEA	molecular_function
GO:0034644	cellular response to UV	IEA	biological_process
GO:0070059	intrinsic apoptotic signaling pathway in response	IEA	biological_process
GO:0001783	B cell apoptotic process	IEA	biological_process
GO:0046902	regulation of mitochondrial membrane permeability	IEA	biological_process
GO:0001782	B cell homeostasis	IEA	biological_process
GO:0035108	limb morphogenesis	IEA	biological_process
GO:0048087	positive regulation of developmental pigmentation	IEA	biological_process
GO:0097136	Bcl-2 family protein complex	IDA	cellular_component
GO:0009611	response to wounding	IEA	biological_process
GO:0046666	retinal cell programmed cell death	IEA	biological_process
GO:0001783	B cell apoptotic process	IDA	biological_process
GO:0010332	response to gamma radiation	IEA	biological_process
GO:0005739	mitochondrion	IEA	cellular_component
GO:0001822	kidney development	IEA	biological_process
GO:0043497	regulation of protein heterodimerization activity	IPI	biological_process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological_process
GO:0051260	protein homooligomerization	IDA	biological_process
GO:0070059	intrinsic apoptotic signaling pathway in response	IMP	biological_process
GO:0006922	cleavage of lamin involved in execution phase of a	IMP	biological_process
GO:0051726	regulation of cell cycle	IEA	biological_process
GO:0008053	mitochondrial fusion	IDA	biological_process
GO:0042475	odontogenesis of dentin-containing tooth	IEA	biological_process
GO:0045136	development of secondary sexual characteristics	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0006917	induction of apoptosis	IMP	biological_process
GO:0005739	mitochondrion	IDA	cellular_component
GO:0043281	regulation of cysteine-type endopeptidase activity	IEA	biological_process
GO:0021854	hypothalamus development	IEA	biological_process
GO:0005829	cytosol	IDA	cellular_component
GO:0002904	positive regulation of B cell apoptotic process	IEA	biological_process
GO:0043523	regulation of neuron apoptotic process	IEA	biological_process
GO:1990009	retinal cell apoptotic process	IMP	biological_process
GO:0005757	mitochondrial permeability transition pore complex	IDA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0043525	positive regulation of neuron apoptotic process	IEA	biological_process
GO:0060041	retina development in camera-type eye	IEA	biological_process
GO:0009636	response to toxin	IDA	biological_process
GO:0033599	regulation of mammary gland epithelial cell prolif	IEA	biological_process
GO:0002358	B cell homeostatic proliferation	IEA	biological_process
GO:0097193	intrinsic apoptotic signaling pathway	IEA	biological_process
GO:0006919	activation of cysteine-type endopeptidase activity	IEA	biological_process
GO:0008289	lipid binding	IDA	molecular_function
GO:0048873	homeostasis of number of cells within a tissue	IEA	biological_process
GO:0046930	pore complex	IDA	cellular_component
GO:0010524	positive regulation of calcium ion transport into	IEA	biological_process
GO:0042981	regulation of apoptotic process	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network