Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHGC_HUMAN
Description:Rho guanine nucleotide exchange factor (GEF) 12 [Source:HGNC Symbol;Acc:14193]
Location:chr11 q23.3
Node attribute:PPI(target); effector; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S608PPRRPsRHDNSPhosphoSitePlus
Y546SSTMQyVILMYRGS-likePhosphoSitePlus; SysPTM
T1286FPRYRtASQGPPhosphoSitePlus; HPRD; phosphoELM
S635LSTPSsVSPEPPhosphoSitePlus
S41VERIAsHDFDPPhosphoSitePlus; phosphoELM
Y1004LKLSEyPNVEEPhosphoSitePlus
Y1326DIATCySPRTSPhosphoSitePlus
T532EEVLMtAQAVERGS-likePhosphoSitePlus
Y660GTDAGyLPANSPhosphoSitePlus
T632PKHLStPSSVSPhosphoSitePlus
Y551YVILMyMKHLGRGS-likePhosphoSitePlus
S1288RYRTAsQGPQTPhosphoSitePlus; HPRD; phosphoELM
S1544KHSDKs_____PhosphoSitePlus
Y1524KVEESyTILCQPhosphoSitePlus
S22PIRHGsILNREHPRD; SysPTM
S637TPSSVsPEPQDPhosphoSitePlus; HPRD
S341QSLVGsPSTRIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S190MERITsPVLMGHPRD
Y1284QHFPRyRTASQPhosphoSitePlus
S1541LTDKHsDKS__PhosphoSitePlus
S337DTDTQsLVGSPPhosphoSitePlus
S1170EQHGIsVTGLQPhosphoSitePlus
T1525VEESYtILCQRPhosphoSitePlus
S1072ASTADsKHTFSPhosphoSitePlus
Y546SSTMQyVILMYHPRD; SysPTM
S1273GLTEKsVQEDWPhosphoSitePlus
S1327IATCYsPRTSTPhosphoSitePlus
S826GILSPsELRKIRhoGEFPhosphoSitePlus
S1239IAIPDsHLPVSPhosphoSitePlus
S1389AREAHsDENPSPhosphoSitePlus
T736VTEHGtPKPFRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S818FYQRVsREGILRhoGEFPhosphoSitePlus
Y1232EVGEDyQIAIPPhosphoSitePlus
T703DTLDGtPRTLNPhosphoSitePlus

Dephosphorylation site
ARHGC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380942E1271KCOSMICOvarian Cancer20668451
ENSP00000349056M1349IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000380942M1368IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000380942R647CCOSMICOvarian Cancer21720365
ENSP00000349056R210*BIOMARTBreast Cancer21930507, 21930502
ENSP00000380942K927*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000380942E238DCOSMICLung Cancer20668451
ENSP00000380942V746ACOSMICBreast Cancer20668451
ENSP00000380942P875LCOSMICMelanoma21499247
ENSP00000380942G1398RCOSMICBreast Cancer20668451
ENSP00000380942E197VCOSMICLung Cancer20668451

Differential expressed protein
ARHGC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARHGC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANARHGC_HUMANGprotein -> effectorgpDB
GNA13_HUMANARHGC_HUMANGprotein -> effectorgpDB
GNA12_HUMANARHGC_HUMANGprotein -> effectorgpDB
ARHG7_HUMANARHGC_HUMANotherKEGG
GNA13_HUMANARHGC_HUMANotherKEGG
ARHGC_HUMANRHOA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa04810Regulation of actin cytoskeleton
hsa04360Axon guidance
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005543phospholipid bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0001664G-protein coupled receptor bindingIDAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005096GTPase activator activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007411axon guidanceTASbiological_process


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