Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANXA1_HUMAN
Description:annexin A1 [Source:HGNC Symbol;Acc:533]
Location:chr9 q21.13
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T88AYLQEtGKPLDAnnexinPhosphoSitePlus
Y21NEEQEyVQTVKEGFRphosphoELM; RegPhos; SysPTM
S28QTVKSsKGGPGPhosphoSitePlus
T41VSPYPtFNPSSPhosphoSitePlus
S5FLKQTRPM7HPRD
S45PTFNPsSDVAAPhosphoSitePlus
S34KGGPGsAVSPYPhosphoSitePlus
T70IIDILtKRNNAAnnexinPhosphoSitePlus
Y39SAVSPyPTFNPPhosphoSitePlus; HPRD; phosphoELM
S5MAMVSeFLKQChaK1(TRPM7RegPhos
Y207DARALyEAGERAnnexinPhosphoSitePlus
T24QEYVQtVKSSKPKC_groupphosphoELM; RegPhos
S27VQTVKsSKGGPPKCa(PKC alphaRegPhos
T169LAKDItSDTSGAnnexinPhosphoSitePlus
S27VQTVKsSKGGPPhosphoSitePlus
T24QEYVQtVKSSKRegPhos
S28QTVKSsKGGPGPKC_groupphosphoELM; RegPhos
T226FNTILtTRSYPAnnexinPhosphoSitePlus
Y21NEEQEyVQTVKPhosphoSitePlus; SysPTM
T216ERRKGtDVNVFHPRD; RegPhos
S27VQTVKsSKGGPPKCiRegPhos
Y21NEEQEyVQTVKSrcRegPhos; SysPTM
S37PGSAVsPYPTFPhosphoSitePlus; HPRD
S170AKDITsDTSGDHPRD; SysPTM
T172DITSDtSGDFRAnnexinPhosphoSitePlus
T216ERRKGtDVNVFPKA_groupphosphoELM; RegPhos
Y21NEEQEyVQTVKAblphosphoELM; SysPTM
Y21NEEQEyVQTVKSRCHPRD; phosphoELM; RegPhos; SysPTM
S5MAMVSeFLKQChaK1RegPhos
S5MAMVSeFLKQRegPhos
S27VQTVKsSKGGPPKC_groupphosphoELM; RegPhos
S27VQTVKsSKGGPPRKCIHPRD
S5_MAMVsEFLKQPhosphoSitePlus
S27VQTVKsSKGGPPKC_alphaphosphoELM
Y240RVFQKyTKYSKAnnexinPhosphoSitePlus
T216ERRKGtDVNVFAnnexinPhosphoSitePlus
Y335ETKGDyEKILVAnnexinPhosphoSitePlus
Y21NEEQEyVQTVKABL1RegPhos; SysPTM
S5FLKQphosphoELM
S170AKDITsDTSGDAnnexinPhosphoSitePlus; SysPTM
T64GVDEAtIIDILAnnexinPhosphoSitePlus
Y207DARALyEAGERHPRD; phosphoELM; RegPhos
Y84QIKAAyLQETGAnnexinPhosphoSitePlus
Y230LTTRSyPQLRRAnnexinPhosphoSitePlus
S173ITSDTsGDFRNAnnexinPhosphoSitePlus

Dephosphorylation site
ANXA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366109*347CCOSMICOvarian Cancer21720365
ENSP00000257497G333ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000366109G333ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000257497G333ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000366109*347SCOSMICOvarian Cancer21720365
ENSP00000257497*347CCOSMICOvarian Cancer21720365
ENSP00000366109G333ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000257497*347SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366109Non-small cell lung carcinomaMetastasiscell lineDown17537172
ENSP00000366109Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000366109Prostate CancerMetastasiscell lineUp8.315102926
ENSP00000366109Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000366109colorectal cancerMetastasiscell lineDown17503081
ENSP00000366109papillary thyroid carcinomaNormal vs. CancertissueUp3.916788983
ENSP00000366109papillary thyroid carcinomaNormal vs. CancertissueUp516788983
ENSP00000366109papillary thyroid carcinomaNormal vs. CancertissueUp1318665625
ENSP00000366109papillary thyroid carcinomaNormal vs. CancertissueUp5.718665625
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.2419142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.2519142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.2819142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.3219142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.3319142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.3619142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.419142970
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.4119142970
ENSP00000366109Breast CancerTreatment (metastasis vs. metastasis-suppressed BRMS1)cell lineDown15168732
ENSP00000366109Breast CancerTreatment (chemosensitive vs. adriamycin-resistant)cell lineUp17487377
ENSP00000366109Neoplasms by Histologic TypeNormal vs. CancertissueUp3.118259946
ENSP00000366109Neoplasms by Histologic TypeNormal vs. CancertissueUp1.918259946
ENSP00000366109Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000366109Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000366109Non-small cell lung carcinomaMetastasiscell lineDown0.2817418446
ENSP00000366109Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp319137550
ENSP00000366109Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp3.319137550
ENSP00000366109Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineUp19795389
ENSP00000366109Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000366109Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp2.418253933
ENSP00000366109Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueDown0.3818830628
ENSP00000366109Gastric CancerNormal vs. CancertissueUp719330469
ENSP00000366109Breast CancerNormal vs. Cancercell lineDown0.2520052998
ENSP00000366109Breast CancerNormal vs. Cancercell lineDown0.9720052998
ENSP00000366109Breast CancerMetastasiscell lineUp420052998
ENSP00000366109Breast CancerNormal vs. CancertissueUp1.820087651
ENSP00000366109Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000366109Breast CancerNormal vs. CancertissueDown20560667
ENSP00000366109Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000366109Breast CancerNormal vs. CancertissueDown0.7420739354
ENSP00000366109Breast CancerNormal vs. CancertissueDown0.7420739354
ENSP00000366109breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000366109Oral CancerNormal vs. CancertissueDown0.219691830
ENSP00000366109chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000366109LeukemiaCancer vs. Cancer (subtype)tissueUp15501966
ENSP00000366109Renal CancerNormal vs. CancertissueUp1.1-5.712923786
ENSP00000366109Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.416807943
ENSP00000366109Ovarian CancerMetastasiscell lineUp317892554
ENSP00000366109Ovarian CancerMetastasiscell lineDown17892554
ENSP00000366109Pancreatic CancerNormal vs. CancertissueUp415526344
ENSP00000366109Esophageal CancerNormal vs. CancertissueDown0.516400690
ENSP00000366109Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000366109Uterine CancerNormal vs. CancertissueDown19771267

Hyperphosphorylation site
ANXA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANXA1_HUMANFPR1_HUMANligand -> receptorHPMR
TRPM7_HUMANANXA1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANANXA1_HUMANkinase -> substrateRegPhos
ABL1_HUMANANXA1_HUMANkinase -> substrateRegPhos
FGR_HUMANANXA1_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANANXA1_HUMANkinase -> substrateHPRD
SRC_HUMANANXA1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANANXA1_HUMANkinase -> substrateRegPhos
KPCA_HUMANANXA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ANXA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceIEAcellular_component
GO:0005544calcium-dependent phospholipid bindingIEAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005102receptor bindingTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0018149peptide cross-linkingIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0031966mitochondrial membraneIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005543phospholipid bindingTASmolecular_function
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0097350neutrophil clearanceIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0001780neutrophil homeostasisIEAbiological_process
GO:0031340positive regulation of vesicle fusionIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0050482arachidonic acid secretionIEAbiological_process
GO:0005198structural molecule activityIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0030073insulin secretionIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0006928cellular component movementTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0005929ciliumIEAcellular_component
GO:0030674protein binding, bridgingIDAmolecular_function
GO:0070365hepatocyte differentiationIEAbiological_process
GO:0030216keratinocyte differentiationIDAbiological_process
GO:0070301cellular response to hydrogen peroxideIEAbiological_process
GO:0046632alpha-beta T cell differentiationIEAbiological_process
GO:0060206estrous cycle phaseIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0001533cornified envelopeIDAcellular_component
GO:0071385cellular response to glucocorticoid stimulusIEAbiological_process
GO:0050709negative regulation of protein secretionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0002674negative regulation of acute inflammatory responseIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0010165response to X-rayIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0031394positive regulation of prostaglandin biosynthetic IEAbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0070555response to interleukin-1IEAbiological_process
GO:0042063gliogenesisIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0031960response to corticosteroid stimulusIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0019834phospholipase A2 inhibitor activityIEAmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0033031positive regulation of neutrophil apoptotic procesIEAbiological_process