| UniProt/SwissProt ID: | SIVA_HUMAN |
| Description: | SIVA1, apoptosis-inducing factor [Source:HGNC Symbol;Acc:17712] |
| Location: | chr14 q32.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y34 | VCAERySQEVF | Abl2 | phosphoELM |
| Y53 | LGAQAyLDHVW | Siva | PhosphoSitePlus |
| Y34 | VCAERySQEVF | ABL2 | RegPhos |
| Y162 | DCSDMyEKVLC | Siva | PhosphoSitePlus |
| Y34 | VCAERySQEVF | Siva | PhosphoSitePlus |
| Dephosphorylation site |
| SIVA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SIVA_HUMAN do not have mutation site. |
| Differential expressed protein |
| SIVA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SIVA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL2_HUMAN | SIVA_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SIVA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0001618 | viral receptor activity | ISS | molecular_function |
| GO:0006924 | activation-induced cell death of T cells | IDA | biological_process |
| GO:0005175 | CD27 receptor binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0032088 | negative regulation of NF-kappaB transcription fac | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0009615 | response to virus | ISS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0008656 | cysteine-type endopeptidase activator activity inv | IDA | molecular_function |
| GO:0006917 | induction of apoptosis | IDA | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0008635 | activation of cysteine-type endopeptidase activity | IDA | biological_process |
| GO:0008270 | zinc ion binding | IDA | molecular_function |