| UniProt/SwissProt ID: | AA3R_HUMAN |
| Description: | adenosine A3 receptor [Source:HGNC Symbol;Acc:268] |
| Location: | chr1 p13.2 |
| Node attribute: | GPCR |
| Phosphorylation site |
| AA3R_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| AA3R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000241356 | A105T | HPI | Colorectal Cancer | 16959974 | ENSP00000358730 | A105T | Sjoblom2006 | Intestines Cancer | 16959974 | ENSP00000241356 | F80Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358730 | R111W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000241356 | R111W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000241356 | A299T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358730 | G190V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000241356 | M174I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000241356 | A105T | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| AA3R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AA3R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AA3R_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| AA3R_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| AA3R_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| AA3R_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050850 | positive regulation of calcium-mediated signaling | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0001973 | adenosine receptor signaling pathway | IEA | biological_process |
| GO:0001609 | G-protein coupled adenosine receptor activity | IEA | molecular_function |
| GO:0007190 | activation of adenylate cyclase activity | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0050729 | positive regulation of inflammatory response | IEA | biological_process |
| GO:0009611 | response to wounding | TAS | biological_process |
| GO:0070257 | positive regulation of mucus secretion | IEA | biological_process |
| GO:0008016 | regulation of heart contraction | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kina | IEA | biological_process |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043306 | positive regulation of mast cell degranulation | IEA | biological_process |
| GO:0002687 | positive regulation of leukocyte migration | IEA | biological_process |
| GO:0002553 | histamine secretion by mast cell | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |