| UniProt/SwissProt ID: | 5HT1E_HUMAN |
| Description: | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled [Source:HGNC Symbol;Acc:5291] |
| Location: | chr6 q14.3 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T50 | MAIGTtKKLHQ | 7tm_1 | PhosphoSitePlus |
| T49 | IMAIGtTKKLH | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| 5HT1E_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307766 | T49N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000358597 | P267S | COSMIC | Melanoma | 21499247 | ENSP00000358597 | R164H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358597 | G91R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358597 | T49N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000358597 | T49N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307766 | R164H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| 5HT1E_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 5HT1E_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPH1_HUMAN | 5HT1E_HUMAN | ligand -> receptor | HPMR |
| 5HT1E_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1E_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1E_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1E_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04726 | Serotonergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0004993 | serotonin receptor activity | IDA | molecular_function |
| GO:0007210 | serotonin receptor signaling pathway | IDA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0051378 | serotonin binding | IDA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |