Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT1E_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled [Source:HGNC Symbol;Acc:5291]
Location:chr6 q14.3
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T50MAIGTtKKLHQ7tm_1PhosphoSitePlus
T49IMAIGtTKKLH7tm_1PhosphoSitePlus

Dephosphorylation site
5HT1E_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000307766T49NTCGAOvarian Cancer21720365, 18772890
ENSP00000358597P267SCOSMICMelanoma21499247
ENSP00000358597R164HBIOMARTBreast Cancer21930507, 21930502
ENSP00000358597G91RCOSMICOvarian Cancer21720365
ENSP00000358597T49NTCGAOvarian Cancer21720365, 18772890
ENSP00000358597T49NCOSMICOvarian Cancer21720365
ENSP00000307766R164HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
5HT1E_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT1E_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT1E_HUMANligand -> receptorHPMR
5HT1E_HUMANGNAI1_HUMANGPCR -> GproteingpDB
5HT1E_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT1E_HUMANGNAI2_HUMANGPCR -> GproteingpDB
5HT1E_HUMANGNAI3_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04726Serotonergic synapse
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004993serotonin receptor activityIDAmolecular_function
GO:0007210serotonin receptor signaling pathwayIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0051378serotonin bindingIDAmolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function


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