Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:4EBP1_HUMAN
Description:eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:3288]
Location:chr8 p11.23
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T46TLFSTtPGGTRFRAPRegPhos
S2____MsGGSSCeIF_4EBPPhosphoSitePlus
S101SHLRNsPEDKRHPRD; phosphoELM; RegPhos
T70SPVTKtPPRDLFRAPRegPhos; SysPTM
T45GTLFStTPGGTeIF_4EBPPhosphoSitePlus
T70SPVTKtPPRDLMTORHPRD; SysPTM
S65MECRNsPVTKTmTORphosphoELM; SysPTM
T37GDYSTtPGGTLMTORHPRD
S94PPMEAsQSHLRHPRD; phosphoELM; RegPhos; SysPTM
S112AGGEEsQFEMDCK2a1-rsRegPhos; SysPTM
T68RNSPVtKTPPRHPRD; RegPhos
T46TLFSTtPGGTRmTORphosphoELM
S83IPGVTsPSSDEMTORHPRD; SysPTM
S83IPGVTsPSSDEMAPK1HPRD; SysPTM
S35PPGDYsTTPGGeIF_4EBPPhosphoSitePlus
Y34LPPGDySTTPGeIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTFRAPRegPhos; SysPTM
S83IPGVTsPSSDEmTORphosphoELM; SysPTM
S101SHLRNsPEDKRmTORphosphoELM
T70SPVTKtPPRDLFRAP(mTORRegPhos; SysPTM
S65MECRNsPVTKTHPRD; phosphoELM; SysPTM
S112AGGEEsQFEMDCK2a2RegPhos; SysPTM
T36PGDYStTPGGTeIF_4EBPPhosphoSitePlus
S101SHLRNsPEDKRFRAP(mTORRegPhos
T82TIPGVtSPSSDeIF_4EBPPhosphoSitePlus
S112AGGEEsQFEMDCK2a1RegPhos; SysPTM
S112AGGEEsQFEMCSNK2A2HPRD; SysPTM
T45GTLFStTPGGTRPS6KA5HPRD
S65MECRNsPVTKTMSK1RegPhos; SysPTM
T36PGDYStTPGGTphosphoELM
Y34LPPGDySTTPGHPRD
T46TLFSTtPGGTRFRAP(mTORRegPhos
S112AGGEEsQFEMDATMRegPhos; SysPTM
S5_MSGGsSCSQTeIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTMAPK1HPRD; SysPTM
S65MECRNsPVTKTeIF_4EBPPhosphoSitePlus; SysPTM
T37GDYSTtPGGTLFRAP(mTORRegPhos
S112AGGEEsQFEMCSNK2A1HPRD; SysPTM
T77PRDLPtIPGVTHPRD
T37GDYSTtPGGTLMAPK1HPRD
S112AGGEEsQFEMDeIF_4EBPPhosphoSitePlus; SysPTM
S44GGTLFsTTPGGHPRD
T46TLFSTtPGGTRp38aRegPhos
T37GDYSTtPGGTLMAPK14HPRD
S65MECRNsPVTKTErk1(MAPK3RegPhos; SysPTM
S8GGSSCsQTPSRATMphosphoELM; RegPhos
S94PPMEAsQSHLReIF_4EBPPhosphoSitePlus; SysPTM
T70SPVTKtPPRDLHPRD; phosphoELM; RegPhos; SysPTM
T45GTLFStTPGGTMSK1RegPhos
S65MECRNsPVTKTRPS6KA5HPRD; SysPTM
T46TLFSTtPGGTRMAPK14HPRD
S112AGGEEsQFEMphosphoELM; SysPTM
T37GDYSTtPGGTLErk2RegPhos
S96MEASQsHLRNSHPRD
T46TLFSTtPGGTRMAPK1HPRD
T37GDYSTtPGGTLAKT1HPRD; RegPhos
T70SPVTKtPPRDLmTORphosphoELM; SysPTM
S83IPGVTsPSSDEErk2RegPhos; SysPTM
S112AGGEEsQFEMDRegPhos; SysPTM
T41TTPGGtLFSTTeIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTFRAP(mTORRegPhos; SysPTM
T70SPVTKtPPRDLeIF_4EBPPhosphoSitePlus; SysPTM
T70SPVTKtPPRDLMAPK1HPRD; SysPTM
T45GTLFStTPGGTRORCHPRD
S65MECRNsPVTKTp38aRegPhos; SysPTM
T41TTPGGtLFSTTHPRD
Y54GTRIIyDRKFLeIF_4EBPPhosphoSitePlus
T37GDYSTtPGGTLFRAPRegPhos
T37GDYSTtPGGTLmTORphosphoELM
T70SPVTKtPPRDLErk2RegPhos; SysPTM
S65MECRNsPVTKTErk2(MAPK1RegPhos; SysPTM
T82TIPGVtSPSSDHPRD
S85GVTSPsSDEPPHPRD; phosphoELM
T46TLFSTtPGGTRAKT1HPRD; RegPhos
S112AGGEEsQFEMATMHPRD; phosphoELM; SysPTM
S85GVTSPsSDEPPeIF_4EBPPhosphoSitePlus
S83IPGVTsPSSDEeIF_4EBPPhosphoSitePlus; SysPTM
T46TLFSTtPGGTRErk2RegPhos
S65MECRNsPVTKTRHEBL1HPRD; SysPTM
T37GDYSTtPGGTLeIF_4EBPPhosphoSitePlus
T46TLFSTtPGGTRMTORHPRD
S44GGTLFsTTPGGeIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTErk2RegPhos; SysPTM
T46TLFSTtPGGTReIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTMAPK14HPRD; SysPTM
S83IPGVTsPSSDEFRAPRegPhos; SysPTM
T46TLFSTtPGGTRRegPhos
T68RNSPVtKTPPReIF_4EBPPhosphoSitePlus
S65MECRNsPVTKTMTORHPRD; SysPTM
S35PPGDYsTTPGGHPRD
T50TTPGGtRIIYDHPRD
T36PGDYStTPGGTRORCHPRD
T50TTPGGtRIIYDeIF_4EBPPhosphoSitePlus
T45GTLFStTPGGTphosphoELM
T36PGDYStTPGGTRPS6KA5HPRD
Y54GTRIIyDRKFLHPRD
S86VTSPSsDEPPMHPRD; SysPTM
S8GGSSCsQTPSReIF_4EBPPhosphoSitePlus
T37GDYSTtPGGTLp38aRegPhos
S101SHLRNsPEDKReIF_4EBPPhosphoSitePlus
S83IPGVTsPSSDEFRAP(mTORRegPhos; SysPTM
S65MECRNsPVTKTAKT1HPRD; RegPhos; SysPTM
T36PGDYStTPGGTMSK1RegPhos

Dephosphorylation site
4EBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340691H97QCOSMICOvarian Cancer21720365

Differential expressed protein
4EBP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T46eIF_4EBPGGTLFSTtPGGTRIIpsoriasis19663871PhosphoSitePlus
T37eIF_4EBPPPGDYSTtPGGTLFSpsoriasis19663871PhosphoSitePlus
T37eIF_4EBPPPGDYSTtPGGTLFSovarian epithelial carcinoma21276607PhosphoSitePlus
T46eIF_4EBPGGTLFSTtPGGTRIIovarian epithelial carcinoma21276607PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
RORG_HUMAN4EBP1_HUMANkinase -> substrateHPRD
MK01_HUMAN4EBP1_HUMANkinase -> substrateHPRD
ATM_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
CSK21_HUMAN4EBP1_HUMANkinase -> substrateHPRD
MTOR_HUMAN4EBP1_HUMANkinase -> substrateRegPhos; NetPath
AKT1_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
CSK22_HUMAN4EBP1_HUMANkinase -> substrateHPRD
KS6A5_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
REBL1_HUMAN4EBP1_HUMANkinase -> substrateHPRD
MK14_HUMAN4EBP1_HUMANkinase -> substrateHPRD
4EBP1_HUMANIF4E_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05221Acute myeloid leukemia
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa03013RNA transport
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0008190eukaryotic initiation factor 4E bindingIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0031929TOR signaling cascadeIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006412translationTASbiological_process
GO:0031369translation initiation factor bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0031333negative regulation of protein complex assemblyIEAbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0045947negative regulation of translational initiationIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0006413translational initiationTASbiological_process
GO:0005634nucleusIEAcellular_component


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