| UniProt/SwissProt ID: | 1433Z_HUMAN |
| Description: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [Source:HGNC Symbol;Acc:12855] |
| Location: | chr8 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y149 | QSQQAyQEAFE | 14-3-3; CIA30; TPR_12 | PhosphoSitePlus |
| Y82 | QMAREyREKIE | 14-3-3; FliM | PhosphoSitePlus |
| S184 | YEILNsPEKAC | JNK1(MAPK8 | RegPhos |
| S58 | GARRSsWRVVS | PKACa | RegPhos |
| S210 | TLSEEsYKDST | HPRD | |
| S58 | GARRSsWRVVS | PKB_group | phosphoELM |
| S58 | GARRSsWRVVS | PKA_group | phosphoELM; RegPhos |
| S45 | ERNLLsVAYKN | 14-3-3; FliM | PhosphoSitePlus |
| Y126 | MKGDYyRYLAE | 14-3-3; CIA30; TPR_12 | PhosphoSitePlus |
| S63 | SWRVVsSIEQK | 14-3-3; FliM | PhosphoSitePlus |
| T232 | LWTSDtQGDEA | phosphoELM; RegPhos; SysPTM | |
| S184 | YEILNsPEKAC | JNK1 | RegPhos |
| Y48 | LLSVAyKNVVG | 14-3-3; FliM | PhosphoSitePlus |
| T232 | LWTSDtQGDEA | CSNK1A1 | HPRD; SysPTM |
| S58 | GARRSsWRVVS | STK25 | HPRD |
| S230 | LTLWTsDTQGD | 14-3-3 | PhosphoSitePlus |
| T232 | LWTSDtQGDEA | CK1_alpha | phosphoELM; SysPTM |
| S184 | YEILNsPEKAC | AKT1 | HPRD; RegPhos |
| S58 | GARRSsWRVVS | HPRD; phosphoELM | |
| S58 | GARRSsWRVVS | PKCd | RegPhos |
| Y178 | NFSVFyYEILN | 14-3-3; CIA30; TPR_12 | PhosphoSitePlus |
| Y125 | KMKGDyYRYLA | 14-3-3; CIA30; TPR_12 | PhosphoSitePlus |
| T205 | IAELDtLSEES | HPRD | |
| T229 | NLTLWtSDTQG | 14-3-3 | PhosphoSitePlus |
| S184 | YEILNsPEKAC | 14-3-3; CIA30; TPR_12 | PhosphoSitePlus |
| Y211 | LSEESyKDSTL | 14-3-3 | PhosphoSitePlus |
| S207 | ELDTLsEESYK | 14-3-3 | PhosphoSitePlus |
| S58 | GARRSsWRVVS | PRKCD | HPRD |
| S230 | LTLWTsDTQGD | HPRD | |
| S58 | GARRSsWRVVS | AKT1 | HPRD; RegPhos |
| T232 | LWTSDtQGDEA | CK1a(CK1 alpha | RegPhos; SysPTM |
| S64 | WRVVSsIEQKT | 14-3-3; FliM | PhosphoSitePlus |
| S58 | GARRSsWRVVS | 14-3-3; FliM | PhosphoSitePlus |
| T194 | CSLAKtAFDEA | 14-3-3; TPR_12 | PhosphoSitePlus |
| S207 | ELDTLsEESYK | HPRD | |
| T232 | LWTSDtQGDEA | 14-3-3 | PhosphoSitePlus; SysPTM |
| T232 | LWTSDtQGDEA | CK1a | RegPhos; SysPTM |
| S184 | YEILNsPEKAC | MAPK8 | HPRD; phosphoELM |
| S58 | GARRSsWRVVS | MAPKAPK2 | HPRD; RegPhos |
| S184 | YEILNsPEKAC | RegPhos | |
| S58 | GARRSsWRVVS | AKT_group | RegPhos |
| T215 | SYKDStLIMQL | 14-3-3 | PhosphoSitePlus |
| Dephosphorylation site |
| 1433Z_HUMAN do not have dephosphorylation site. |
| Mutation site |
| 1433Z_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1 | 19072117 | ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 3.1 | 19072117 | ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.2 | 19072117 | ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.9 | 19072117 | ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Down | 0.81 | 19072117 | ENSP00000379288 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.5 | 19072117 | ENSP00000379288 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.2 | 19142970 | ENSP00000379288 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 15559763 | ENSP00000379288 | Gastric Cancer | Metastasis | cell line | Up | 1.5 | 17022644 | ENSP00000379288 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.5 | 19330469 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3.3 | 20005186 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3.8 | 20005186 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.44 | 20052998 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.23 | 20052998 | ENSP00000379288 | Breast Cancer | Metastasis | cell line | Down | 0.54 | 20052998 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.51 | 20052998 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.1 | 20052998 | ENSP00000379288 | Breast Cancer | Metastasis | cell line | Up | 2.3 | 20052998 | ENSP00000379288 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 1000 | 20534901 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.71 | 20543960 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.66 | 20543960 | ENSP00000379288 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.68 | 20543960 | ENSP00000379288 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | ENSP00000379288 | Renal Cancer | Normal vs. Cancer | tissue | Up | 19164279 | ENSP00000379288 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.32 | 15761955 |
| Hyperphosphorylation site |
| 1433Z_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | 1433Z_HUMAN | kinase -> substrate | RegPhos |
| MAPK2_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD; RegPhos |
| STK25_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD |
| LYN_HUMAN | 1433Z_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK3_HUMAN | 1433Z_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| YES_HUMAN | 1433Z_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | 1433Z_HUMAN | kinase -> substrate | RegPhos |
| KPCD_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD |
| MK08_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04114 | Oocyte meiosis |
| hsa04110 | Cell cycle |
| hsa05169 | Epstein-Barr virus infection |
| hsa05203 | Viral carcinogenesis |
| hsa05130 | Pathogenic Escherichia coli infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0006626 | protein targeting to mitochondrion | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0031252 | cell leading edge | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0010941 | regulation of cell death | IEA | biological_process |
| GO:0006605 | protein targeting | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0002553 | histamine secretion by mast cell | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | TAS | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |