Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:XRCC4_HUMAN
Description:X-ray repair complementing defective repair in Chinese hamster cells 4 [Source:HGNC Symbol;Acc:12831]
Location:chr5 q14.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S6MERKIsRIHLVXRCC4PhosphoSitePlus
S327ETLRNsSPEDLXRCC4; DUF3629PhosphoSitePlus
S327ETLRNsSPEDLHPRD; phosphoELM; RegPhos
S315KKEHIsAENMSHPRD; phosphoELM; RegPhos
S320SAENMsLETLRDNAPKRegPhos
S325ETLRNsSPEDLHPRD
T17SEPSItHFLQVXRCC4PhosphoSitePlus
S320SAENMsLETLRHPRD; phosphoELM; RegPhos
S304SRPDSsLPETSXRCC4; DUF3629PhosphoSitePlus
T323NMSLEtLRNSSHPRD; phosphoELM; RegPhos
S193KTKIRsLHNKLphosphoELM; RegPhos
S256VSKDDsIISSLXRCC4; DUF3629PhosphoSitePlus
T321NMSLEtLRNSSHPRD
S260DSIISsLDVTDphosphoELM; RegPhos
S313KKEHIsAENMSHPRD
S260DSIISsLDVTDXRCC4; DUF3629PhosphoSitePlus
S256VSKDDsIISSLHPRD
S328TLRNSsPEDLFHPRD; phosphoELM; RegPhos
S328TLRNSsPEDLFXRCC4; DUF3629PhosphoSitePlus
S320SAENMsLETLRXRCC4; DUF3629PhosphoSitePlus
T233VYDEStDEESEXRCC4; DUF3629PhosphoSitePlus
S260DSIISsLDVTDDNAPKRegPhos
S318SAENMsLETLRHPRD
S326TLRNSsPEDLFHPRD
S304SRPDSsLPETSphosphoELM; RegPhos
S299QEKENsRPDSSXRCC4; DUF3629PhosphoSitePlus
T323NMSLEtLRNSSXRCC4; DUF3629PhosphoSitePlus

Dephosphorylation site
XRCC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282268I181FCOSMICMelanoma20016485
ENSP00000379344A314SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000379344I181FCOSMICMelanoma20016485
ENSP00000379344G160*COSMICMelanoma21499247
ENSP00000282268G160*COSMICMelanoma21499247

Differential expressed protein
XRCC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
XRCC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANXRCC4_HUMANkinase -> substrateRegPhos
MK08_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016032viral reproductionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0070419nonhomologous end joining complexIDAcellular_component
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDAcellular_component
GO:0033151V(D)J recombinationIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0033152immunoglobulin V(D)J recombinationIEAbiological_process
GO:0032807DNA ligase IV complexIDAcellular_component
GO:0010165response to X-rayIDAbiological_process
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIEAcellular_component
GO:0006303double-strand break repair via nonhomologous end jIDAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0006302double-strand break repairIDAbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0010165response to X-rayIEAbiological_process
GO:0006266DNA ligationIEAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0051103DNA ligation involved in DNA repairIDAbiological_process
GO:0002328pro-B cell differentiationIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007417central nervous system developmentIEAbiological_process
GO:0006303double-strand break repair via nonhomologous end jIEAbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045190isotype switchingIEAbiological_process
GO:0051351positive regulation of ligase activityIDAbiological_process
GO:0010212response to ionizing radiationIEAbiological_process


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