Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:XPO1_HUMAN
Description:exportin 1 (CRM1 homolog, yeast) [Source:HGNC Symbol;Acc:12825]
Location:chr2 p15
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T519KRFLVtVIKDLPhosphoSitePlus
T187SSGQItQVKSKPhosphoSitePlus
S1055HKRQMsVPGIFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S389SPFSTsASPLLPhosphoSitePlus; HPRD
S802EPEVLsTMAIIPhosphoSitePlus
Y409PRRQLyLPMLFPhosphoSitePlus
T65WTRVDtILEFSIBN_NPhosphoSitePlus
S391FSTSAsPLLSGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1031AGEDTsDLFLEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T65WTRVDtILEFSHPRD
Y252ISTLIyKFLNVPhosphoSitePlus
T816LGGHItAEIPQPhosphoSitePlus
T1030FAGEDtSDLFLHPRD
S264MFRNVsLKCLTPhosphoSitePlus
S387RESPFsTSASPHPRD
S764ISGWVsRSNDPPhosphoSitePlus; HPRD
S397PLLSGsQHFDVPhosphoSitePlus; HPRD; phosphoELM
S395ASPLLsGSQHFPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
XPO1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384863E571KCOSMICLymphoma21642962
ENSP00000385559K531ICOSMICHead and Neck Cancer21798893
ENSP00000385942P964HCOSMICSkin Cancer21984974
ENSP00000385559E383KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385942D612NCOSMICHead and Neck Cancer21798893
ENSP00000385559E571KCOSMICLymphoma21642962
ENSP00000384863D612NCOSMICHead and Neck Cancer21798893
ENSP00000384863E383KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385942V189ICOSMICHead and Neck Cancer21798893
ENSP00000385559V189ICOSMICHead and Neck Cancer21798893
ENSP00000385942E383KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000385559D612NCOSMICHead and Neck Cancer21798893
ENSP00000385942E571KCOSMICLymphoma21642962
ENSP00000385559P964HCOSMICSkin Cancer21984974
ENSP00000384863K531ICOSMICHead and Neck Cancer21798893
ENSP00000384863P964HCOSMICSkin Cancer21984974
ENSP00000384863V189ICOSMICHead and Neck Cancer21798893
ENSP00000385942K531ICOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000385559Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
XPO1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK2_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
UHMK1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
XPO1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003723RNA bindingIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010824regulation of centrosome duplicationIEAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0015030Cajal bodyIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005635nuclear envelopeTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0005488bindingIEAmolecular_function
GO:0016070RNA metabolic processTASbiological_process
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0034504protein localization to nucleusIEAbiological_process
GO:0006611protein export from nucleusIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005643nuclear poreIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0042176regulation of protein catabolic processIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005215transporter activityTASmolecular_function
GO:0019058viral infectious cycleTASbiological_process
GO:0006886intracellular protein transportIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0046825regulation of protein export from nucleusIEAbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0005642annulate lamellaeIDAcellular_component
GO:0008565protein transporter activityIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0051028mRNA transportIEAbiological_process
GO:0016071mRNA metabolic processTASbiological_process


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