Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WNT5A_HUMAN
Description:wingless-type MMTV integration site family, member 5A [Source:HGNC Symbol;Acc:12784]
Location:chr3 p14.3
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T121STVDNtSVFGRwntPhosphoSitePlus
S122TVDNTsVFGRVwntPhosphoSitePlus
T117RWNCStVDNTSwntPhosphoSitePlus
S116RRWNCsTVDNTwntPhosphoSitePlus

Dephosphorylation site
WNT5A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264634Q56*BIOMARTBreast Cancer21930507, 21930502
ENSP00000417310Q56*BIOMARTBreast Cancer21930507, 21930502
ENSP00000420104Q41*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
WNT5A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WNT5A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT5A_HUMANRYK_HUMANligand -> receptorHPMR
WNT5A_HUMANFZD7_HUMANligand -> receptorHPMR
WNT5A_HUMANFZD2_HUMANligand -> receptorHPMR
WNT5A_HUMANFZD4_HUMANligand -> receptorHPMR
WNT5A_HUMANFZD10_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa05166HTLV-I infection
hsa04916Melanogenesis
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008584male gonad developmentIEAbiological_process
GO:0048850hypophysis morphogenesisIEAbiological_process
GO:0003344pericardium morphogenesisIBAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0021891olfactory bulb interneuron developmentIEAbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0071346cellular response to interferon-gammaIEPbiological_process
GO:0060744mammary gland branching involved in thelarcheIBAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIBAbiological_process
GO:0060750epithelial cell proliferation involved in mammary IBAbiological_process
GO:0030182neuron differentiationISSbiological_process
GO:0001736establishment of planar polarityIEAbiological_process
GO:0060907positive regulation of macrophage cytokine productIMPbiological_process
GO:0071219cellular response to molecule of bacterial originIEAbiological_process
GO:0060340positive regulation of type I interferon-mediated IDAbiological_process
GO:0001756somitogenesisIBAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0060157urinary bladder developmentIBAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0070245positive regulation of thymocyte apoptotic processIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0036342post-anal tail morphogenesisIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0060324face developmentIMPbiological_process
GO:0051964negative regulation of synapse assemblyIEAbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0090179planar cell polarity pathway involved in neural tuIEAbiological_process
GO:2000484positive regulation of interleukin-8 secretionIEAbiological_process
GO:0060026convergent extensionIEAbiological_process
GO:0060068vagina developmentIEAbiological_process
GO:0071542dopaminergic neuron differentiationIBAbiological_process
GO:0060065uterus developmentIEAbiological_process
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0048843negative regulation of axon extension involved in IEAbiological_process
GO:0061350planar cell polarity pathway involved in cardiac mIEAbiological_process
GO:0030216keratinocyte differentiationIEPbiological_process
GO:0010033response to organic substanceIEPbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0090009primitive streak formationIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0060744mammary gland branching involved in thelarcheIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048706embryonic skeletal system developmentIMPbiological_process
GO:0043032positive regulation of macrophage activationIMPbiological_process
GO:0010820positive regulation of T cell chemotaxisIMPbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0046546development of primary male sexual characteristicsIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:0060750epithelial cell proliferation involved in mammary IEAbiological_process
GO:0045732positive regulation of protein catabolic processIGIbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0060599lateral sprouting involved in mammary gland duct mIEAbiological_process
GO:0090103cochlea morphogenesisIBAbiological_process
GO:0071425hematopoietic stem cell proliferationIDAbiological_process
GO:0009950dorsal/ventral axis specificationIBAbiological_process
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0060067cervix developmentIBAbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0030825positive regulation of cGMP metabolic processIDAbiological_process
GO:0005110frizzled-2 bindingIEAmolecular_function
GO:0007223Wnt receptor signaling pathway, calcium modulatingIMPbiological_process
GO:0050718positive regulation of interleukin-1 beta secretioIMPbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0072201negative regulation of mesenchymal cell proliferatIDAbiological_process
GO:0060762regulation of branching involved in mammary gland IEAbiological_process
GO:0034613cellular protein localizationIEAbiological_process
GO:0008595anterior/posterior axis specification, embryoIEAbiological_process
GO:0005886plasma membraneIBAcellular_component
GO:0071277cellular response to calcium ionIEPbiological_process
GO:0005109frizzled bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0005110frizzled-2 bindingIBAmolecular_function
GO:0061036positive regulation of cartilage developmentIBAbiological_process
GO:0001843neural tube closureIBAbiological_process
GO:0060606tube closureIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0050718positive regulation of interleukin-1 beta secretioIEAbiological_process
GO:0003323type B pancreatic cell developmentIEAbiological_process
GO:0048546digestive tract morphogenesisIBAbiological_process
GO:0060762regulation of branching involved in mammary gland IBAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0007442hindgut morphogenesisIEAbiological_process
GO:0003344pericardium morphogenesisIEAbiological_process
GO:0060029convergent extension involved in organogenesisIEAbiological_process
GO:2000049positive regulation of cell-cell adhesion mediatedIEAbiological_process
GO:0002741positive regulation of cytokine secretion involvedIMPbiological_process
GO:0010800positive regulation of peptidyl-threonine phosphorIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0003408optic cup formation involved in camera-type eye deISSbiological_process
GO:0060065uterus developmentIBAbiological_process
GO:0032755positive regulation of interleukin-6 productionIMPbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0071425hematopoietic stem cell proliferationIEAbiological_process
GO:0070245positive regulation of thymocyte apoptotic processIBAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0060021palate developmentIMPbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0016055Wnt receptor signaling pathwayIDAbiological_process
GO:0061347planar cell polarity pathway involved in outflow tIEAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0038031non-canonical Wnt receptor signaling pathway via JIEAbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0003401axis elongationIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0090037positive regulation of protein kinase C signaling IMPbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0048806genitalia developmentIMPbiological_process
GO:0060760positive regulation of response to cytokine stimulIDAbiological_process
GO:0042060wound healingIDAbiological_process
GO:0045080positive regulation of chemokine biosynthetic procIMPbiological_process
GO:0010976positive regulation of neuron projection developmeISSbiological_process
GO:0007223Wnt receptor signaling pathway, calcium modulatingIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0061349planar cell polarity pathway involved in cardiac rIEAbiological_process
GO:0060599lateral sprouting involved in mammary gland duct mIBAbiological_process
GO:0045778positive regulation of ossificationIMPbiological_process
GO:0050919negative chemotaxisIEAbiological_process
GO:0060541respiratory system developmentIBAbiological_process
GO:0003323type B pancreatic cell developmentIBAbiological_process
GO:0008584male gonad developmentIEPbiological_process
GO:0045836positive regulation of meiosisIEAbiological_process
GO:0071542dopaminergic neuron differentiationIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIEPbiological_process
GO:0060157urinary bladder developmentIEAbiological_process
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0035108limb morphogenesisIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0001667ameboidal cell migrationIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIBAbiological_process
GO:0046330positive regulation of JNK cascadeIBAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIBAbiological_process
GO:0002088lens development in camera-type eyeISSbiological_process
GO:0007257activation of JUN kinase activityIMPbiological_process
GO:0001947heart loopingIBAbiological_process
GO:0071222cellular response to lipopolysaccharideIEPbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0071300cellular response to retinoic acidISSbiological_process
GO:0071560cellular response to transforming growth factor beIEPbiological_process
GO:0042733embryonic digit morphogenesisIBAbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0061348planar cell polarity pathway involved in ventriculIEAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0090009primitive streak formationIBAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0061036positive regulation of cartilage developmentIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0060686negative regulation of prostatic bud formationIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIGIbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0007494midgut developmentIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0048018receptor agonist activityICmolecular_function
GO:0050729positive regulation of inflammatory responseIMPbiological_process
GO:0021891olfactory bulb interneuron developmentISSbiological_process
GO:0005109frizzled bindingIEAmolecular_function
GO:0002009morphogenesis of an epitheliumIEAbiological_process
GO:0034613cellular protein localizationIDAbiological_process
GO:0045599negative regulation of fat cell differentiationIMPbiological_process
GO:0060638mesenchymal-epithelial cell signalingIEAbiological_process
GO:0005115receptor tyrosine kinase-like orphan receptor bindIPImolecular_function
GO:0061354planar cell polarity pathway involved in pericardiIEAbiological_process
GO:0040037negative regulation of fibroblast growth factor reIBAbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0060067cervix developmentIEAbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0060068vagina developmentIBAbiological_process
GO:0060029convergent extension involved in organogenesisIBAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIMPmolecular_function