Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FZD2_HUMAN
Description:frizzled family receptor 2 [Source:HGNC Symbol;Acc:4040]
Location:chr17 q21.31
Node attribute:receptor; GPCR

Phosphorylation site
FZD2_HUMAN do not have phosphorylation site.

Dephosphorylation site
FZD2_HUMAN do not have dephosphorylation site.

Mutation site
FZD2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000323901Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3215169874
ENSP00000323901Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
FZD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT5A_HUMANFZD2_HUMANligand -> receptorHPMR
WNT4_HUMANFZD2_HUMANligand -> receptorHPMR
FZD2_HUMANGNA11_HUMANGPCR -> GproteingpDB
FZD2_HUMANGNAT1_HUMANGPCR -> GproteingpDB
FZD2_HUMANGNAQ_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007199G-protein coupled receptor signaling pathway couplIBAbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0030182neuron differentiationISSbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0030825positive regulation of cGMP metabolic processIMPbiological_process
GO:0007223Wnt receptor signaling pathway, calcium modulatingIBAbiological_process
GO:0032589neuron projection membraneIBAcellular_component
GO:0007608sensory perception of smellIEAbiological_process
GO:0090179planar cell polarity pathway involved in neural tuIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007409axonogenesisIBAbiological_process
GO:0003150muscular septum morphogenesisIEAbiological_process
GO:0007420brain developmentIBAbiological_process
GO:0060022hard palate developmentIEAbiological_process
GO:0060119inner ear receptor cell developmentIEAbiological_process
GO:0030165PDZ domain bindingIPImolecular_function
GO:0009790embryo developmentIBAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008406gonad developmentIBAbiological_process
GO:0001944vasculature developmentIBAbiological_process
GO:0030855epithelial cell differentiationIBAbiological_process
GO:0003149membranous septum morphogenesisIEAbiological_process
GO:0042813Wnt-activated receptor activityIEAmolecular_function
GO:0060412ventricular septum morphogenesisIEAbiological_process
GO:0045177apical part of cellIBAcellular_component
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component


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