Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RYK_HUMAN
Description:receptor-like tyrosine kinase [Source:HGNC Symbol;Acc:10481]
Location:chr3 q22.2
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T328SRERItLKDVLPkinase_TyrPhosphoSitePlus
S368VKDQAsEIQVTPkinase_TyrPhosphoSitePlus
T337VLQEGtFGRIFPkinase_TyrPhosphoSitePlus
T373SEIQVtMMLTEPkinase_TyrPhosphoSitePlus
T377VTMMLtESCKLPkinase_TyrPhosphoSitePlus
S379MMLTEsCKLRGPkinase_TyrPhosphoSitePlus
T297ITSYPtLRIEKPhosphoSitePlus

Dephosphorylation site
RYK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296084L539VBIOMARTBreast Cancer21930507, 21930502
ENSP00000296084C401RCOSMICHead and Neck Cancer21798893
ENSP00000296084T286ADing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000296084Q273*COSMICBreast Cancer20668451

Differential expressed protein
RYK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RYK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT5A_HUMANRYK_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
RYK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0007411axon guidanceISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0071679commissural neuron axon guidanceIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneISScellular_component
GO:0048843negative regulation of axon extension involved in IEAbiological_process
GO:0050919negative chemotaxisIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0022038corpus callosum developmentIEAbiological_process
GO:0031175neuron projection developmentISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0004888transmembrane signaling receptor activityIDAmolecular_function
GO:0031175neuron projection developmentIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005109frizzled bindingIEAmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0042813Wnt-activated receptor activityIEAmolecular_function
GO:0030182neuron differentiationISSbiological_process
GO:0030182neuron differentiationIEAbiological_process


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