| UniProt/SwissProt ID: | TXK_HUMAN |
| Description: | TXK tyrosine kinase [Source:HGNC Symbol;Acc:12434] |
| Location: | chr4 p12 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y420 | VLDDEyVSSFG | phosphoELM; RegPhos | |
| Y91 | QVKALyDFLPR | RegPhos | |
| Y420 | VLDDEyVSSFG | SRC | HPRD; RegPhos |
| Y91 | QVKALyDFLPR | SH3_1 | PhosphoSitePlus |
| Y91 | QVKALyDFLPR | TXK | HPRD; phosphoELM; RegPhos |
| Y420 | VLDDEyVSSFG | autocatalysis | RegPhos |
| Y420 | VLDDEyVSSFG | Pkinase_Tyr | PhosphoSitePlus |
| Y420 | VLDDEyVSSFG | FYN | HPRD; RegPhos |
| Dephosphorylation site |
| TXK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264316 | A216T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TXK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TXK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | TXK_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath |
| ZAGL2_HUMAN | TXK_HUMAN | kinase -> substrate | RegPhos |
| TXK_HUMAN | TXK_HUMAN | kinase -> substrate | HPRD; RegPhos |
| SRC_HUMAN | TXK_HUMAN | kinase -> substrate | HPRD; RegPhos |
| TXK_HUMAN | LCP2_HUMAN | kinase -> substrate | RegPhos |
| TXK_HUMAN | CTLA4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032729 | positive regulation of interferon-gamma production | IDA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0032633 | interleukin-4 production | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0060335 | positive regulation of interferon-gamma-mediated s | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0050852 | T cell receptor signaling pathway | ISS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001865 | NK T cell differentiation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0002250 | adaptive immune response | ISS | biological_process |
| GO:0001816 | cytokine production | ISS | biological_process |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007202 | activation of phospholipase C activity | ISS | biological_process |
| GO:0032609 | interferon-gamma production | IEA | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0001012 | RNA polymerase II regulatory region DNA binding | IDA | molecular_function |