Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MD1L1_HUMAN
Description:MAD1 mitotic arrest deficient-like 1 (yeast) [Source:HGNC Symbol;Acc:6762]
Location:chr7 p22.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S90LERAAsTSARNMAD; DUF2208PhosphoSitePlus
S428TPAEYsPQLTRMADPhosphoSitePlus; SysPTM
S551SLNPTsVARQRphosphoELM
T323ERLDQtMGLSIHPRD
T13TMVLStLRSLNphosphoELM
S428TPAEYsPQLTRHPRD; phosphoELM; SysPTM
S92RAASTsARNYEphosphoELM
S77MQMELsHKRARphosphoELM
S490SSAEQsFLFSRMADPhosphoSitePlus
Y634FRKACyTLTGYMAD; DUF2856PhosphoSitePlus
T680MQLLEtEFSHTMADPhosphoSitePlus
S490SSAEQsFLFSRHPRD; phosphoELM
T550MSLNPtSVARQHPRD
S12NTMVLsTLRSLHPRD; phosphoELM
Y649TTENQyRLTSLMAD; DUF2856PhosphoSitePlus
S12NTMVLsTLRSLMADPhosphoSitePlus
S29RVEGGsGLDISMADPhosphoSitePlus
T13TMVLStLRSLNMADPhosphoSitePlus
S485LKSQSsSAEQSHPRD
S185VKRLEsEKQELMAD; Reo_sigmaCPhosphoSitePlus
S77MQMELsHKRARMAD; DUF2208PhosphoSitePlus
S22LNNFIsQRVEGMADPhosphoSitePlus
T708FLSSLtLELFSMADPhosphoSitePlus
S562LREDHsQLQAEMADPhosphoSitePlus
S598ASLPSsKEVAEMAD; DUF2856PhosphoSitePlus
S214QELQAsQEARAHPRD; phosphoELM
Y427LTPAEySPQLTHPRD; phosphoELM
Y535ALQGDyDQSRTMADPhosphoSitePlus
T432YSPQLtRRMREMADPhosphoSitePlus
S16LSTLRsLNNFIHPRD; phosphoELM; SysPTM
S90LERAAsTSARNphosphoELM
S551SLNPTsVARQRMADPhosphoSitePlus
S597AASLPsSKEVAMAD; DUF2856PhosphoSitePlus
T583MERGGtVPADLMADPhosphoSitePlus
S699LRRQDsIPAFLMADPhosphoSitePlus
S92RAASTsARNYEMAD; DUF2208PhosphoSitePlus
S377ELRQVsGQLLEMADPhosphoSitePlus
S214QELQAsQEARAMAD; Reo_sigmaCPhosphoSitePlus
S594EAAAAsLPSSKHPRD
S16LSTLRsLNNFIMADPhosphoSitePlus; SysPTM

Dephosphorylation site
MD1L1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385334R360QHPIProstate Cancer11423979
ENSP00000382562T299AHPILung Cancer10597320
ENSP00000385334T299AHPILung Cancer10597320
ENSP00000382562E569KHPIBreast Cancer11423979
ENSP00000382562S29LHPILeukemia11423979
ENSP00000385334R558HHPIOther Cancer10366450 10597320 11423979
ENSP00000385334E516KHPIBreast Cancer11423979
ENSP00000382562R556HHPILung Cancer10597320
ENSP00000385334S29LHPILeukemia11423979
ENSP00000382562R572HHPIOther Cancer10366450
ENSP00000385334R59COMIM, HPIProstate Cancer11423979
ENSP00000382562R59COMIM, HPIProstate Cancer11423979
ENSP00000382562R558HHPIOther Cancer10366450 10597320 11423979
ENSP00000382562E516KHPIBreast Cancer11423979
ENSP00000385334R572HHPIOther Cancer10366450
ENSP00000382562R360QHPIProstate Cancer11423979
ENSP00000385334E569KHPIBreast Cancer11423979
ENSP00000385334R556HHPILung Cancer10597320

Differential expressed protein
MD1L1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MD1L1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TTK_HUMANMD1L1_HUMANkinase -> substrateKEGG
MD1L1_HUMANMD2L2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000093mitotic telophaseNASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0000090mitotic anaphaseNASbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005643nuclear poreIDAcellular_component
GO:0000089mitotic metaphaseNASbiological_process
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005819spindleNAScellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0051301cell divisionIEAbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0007093mitotic cell cycle checkpointNASbiological_process
GO:0005813centrosomeNAScellular_component