| UniProt/SwissProt ID: | TTK_HUMAN |
| Description: | TTK protein kinase [Source:HGNC Symbol;Acc:12401] |
| Location: | chr6 q14.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T12 | SGRELtIDSIM | PhosphoSitePlus | |
| S80 | NSVPLsDALLN | HPRD; SysPTM | |
| Y836 | TLYEHySGGES | PhosphoSitePlus | |
| T288 | DCDVKtDDSVV | PhosphoSitePlus | |
| T805 | QMAKGtTEEMK | PhosphoSitePlus | |
| S265 | VNLLNsPDCDV | phosphoELM | |
| S821 | LVGLNsPNSIL | PhosphoSitePlus; HPRD; SysPTM | |
| S321 | PSGNDsCELRN | PhosphoSitePlus; HPRD; SysPTM | |
| T453 | KSICKtPSSNT | PhosphoSitePlus | |
| S433 | PVFSVsKQSPP | HPRD | |
| Y462 | NTLDDyMSCFR | PhosphoSitePlus | |
| S214 | LTAQEsFSGSL | PhosphoSitePlus | |
| T17 | KNEDLtDELSL | phosphoELM | |
| T675 | QMQPDtTSVVK | Pkinase | PhosphoSitePlus |
| S37 | LTDELsLNKIS | PhosphoSitePlus; HPRD | |
| S742 | IINQIsKLHAI | Pkinase | PhosphoSitePlus |
| S7 | ESEDLsGRELT | PhosphoSitePlus; SysPTM | |
| Y255 | DAEIGyRNSLR | PhosphoSitePlus | |
| S218 | ESFSGsLGHLQ | PhosphoSitePlus | |
| T351 | SELIItDSITL | PhosphoSitePlus; HPRD | |
| S353 | LIITDsITLKN | PhosphoSitePlus; HPRD | |
| S49 | DTTDNsGTVNQ | HPRD | |
| T849 | SSSSKtFEKKR | PhosphoSitePlus | |
| S345 | VSDEKsSELII | HPRD | |
| S363 | NKTESsLLAKL | PhosphoSitePlus | |
| S847 | HNSSSsKTFEK | PhosphoSitePlus | |
| Y833 | AAKTLyEHYSG | PhosphoSitePlus; HPRD | |
| T360 | TLKNKtESSLL | PhosphoSitePlus | |
| S382 | PEVPEsNQKQW | PhosphoSitePlus | |
| T686 | DSQVGtVNYMP | Pkinase | PhosphoSitePlus |
| T795 | YVQIQtHPVNQ | PhosphoSitePlus | |
| T806 | MAKGTtEEMKY | PhosphoSitePlus | |
| S393 | QSKRKsECINQ | PhosphoSitePlus; HPRD; SysPTM | |
| S436 | SVSKQsPPIST | PhosphoSitePlus; HPRD; SysPTM | |
| S455 | ICKTPsSNTLD | PhosphoSitePlus; HPRD | |
| S216 | AQESFsGSLGH | PhosphoSitePlus | |
| S808 | LNSPNsILKAA | phosphoELM | |
| S80 | NSVPLsDALLN | Mad3_BUB1_I | PhosphoSitePlus; SysPTM |
| S3 | ___MEsEDLSG | PhosphoSitePlus | |
| S439 | ICKTPsSNTLD | phosphoELM | |
| S821 | LYEHYsGGESH | phosphoELM; SysPTM | |
| T564 | EADNQtLDSYR | Pkinase; Tubulin | PhosphoSitePlus |
| Y374 | EETKEyQEPEV | PhosphoSitePlus | |
| S281 | VNLLNsPDCDV | PhosphoSitePlus; HPRD; SysPTM | |
| Y811 | TEEMKyVLGQL | PhosphoSitePlus | |
| S317 | PGSKPsGNDSC | PhosphoSitePlus; HPRD; SysPTM | |
| S618 | LKKKKsIDPWE | Pkinase | PhosphoSitePlus |
| S362 | KNKTEsSLLAK | PhosphoSitePlus | |
| S824 | LNSPNsILKAA | PhosphoSitePlus; HPRD | |
| S305 | PSGNDsCELRN | phosphoELM | |
| S845 | ESHNSsSSKTF | PhosphoSitePlus | |
| S258 | IGYRNsLRQTN | PhosphoSitePlus | |
| S582 | KLQQHsDKIIR | Pkinase; Tubulin | PhosphoSitePlus |
| S7 | RELT | HPRD; SysPTM | |
| Y131 | DDARDyFQMAR | Mad3_BUB1_I | PhosphoSitePlus |
| T458 | TPSSNtLDDYM | PhosphoSitePlus | |
| T371 | AKLEEtKEYQE | PhosphoSitePlus | |
| S837 | LYEHYsGGESH | PhosphoSitePlus | |
| S677 | QPDTTsVVKDS | Pkinase | PhosphoSitePlus |
| S15 | ELTIDsIMNKV | PhosphoSitePlus | |
| T468 | MSCFRtPVVKN | PhosphoSitePlus | |
| S805 | LVGLNsPNSIL | phosphoELM | |
| T33 | KNEDLtDELSL | PhosphoSitePlus; HPRD; SysPTM | |
| T676 | MQPDTtSVVKD | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| TTK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358813 | D697Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000358813 | S214* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000358813 | T637R | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| TTK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TTK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TTK_HUMAN | RBBP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TTK_HUMAN | IF2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TTK_HUMAN | MD1L1_HUMAN | kinase -> substrate | KEGG |
| TTK_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007052 | mitotic spindle organization | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0010862 | positive regulation of pathway-restricted SMAD pro | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0005819 | spindle | TAS | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007051 | spindle organization | TAS | biological_process |