Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRFR_HUMAN
Description:thyrotropin-releasing hormone receptor [Source:HGNC Symbol;Acc:12299]
Location:chr8 q23.1
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T342CKQKPtEKPANPhosphoSitePlus
S178DAIVIsCGYKI7tm_1PhosphoSitePlus

Dephosphorylation site
TRFR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000430711W279*COSMICMelanoma21499247
ENSP00000309818P341LCOSMICSkin Cancer21984974
ENSP00000430711P341LCOSMICSkin Cancer21984974
ENSP00000309818S394FCOSMICMelanoma21499247
ENSP00000309818W279*COSMICMelanoma21499247
ENSP00000309818V272ACOSMICLung Cancer20668451
ENSP00000430711V272ACOSMICLung Cancer20668451
ENSP00000430711S394FCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000309818Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.6215169874

Hyperphosphorylation site
TRFR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRH_HUMANTRFR_HUMANligand -> receptorHPMR
TRFR_HUMANGNAQ_HUMANGPCR -> GproteingpDB
TRFR_HUMANGNA11_HUMANGPCR -> GproteingpDB
GLHA_HUMANTRFR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0004997thyrotropin-releasing hormone receptor activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23