| UniProt/SwissProt ID: | TRFR_HUMAN |
| Description: | thyrotropin-releasing hormone receptor [Source:HGNC Symbol;Acc:12299] |
| Location: | chr8 q23.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T342 | CKQKPtEKPAN | PhosphoSitePlus | |
| S178 | DAIVIsCGYKI | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| TRFR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000430711 | W279* | COSMIC | Melanoma | 21499247 | ENSP00000309818 | P341L | COSMIC | Skin Cancer | 21984974 | ENSP00000430711 | P341L | COSMIC | Skin Cancer | 21984974 | ENSP00000309818 | S394F | COSMIC | Melanoma | 21499247 | ENSP00000309818 | W279* | COSMIC | Melanoma | 21499247 | ENSP00000309818 | V272A | COSMIC | Lung Cancer | 20668451 | ENSP00000430711 | V272A | COSMIC | Lung Cancer | 20668451 | ENSP00000430711 | S394F | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000309818 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.62 | 15169874 |
| Hyperphosphorylation site |
| TRFR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TRH_HUMAN | TRFR_HUMAN | ligand -> receptor | HPMR |
| TRFR_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| TRFR_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | TRFR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004997 | thyrotropin-releasing hormone receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |