| UniProt/SwissProt ID: | TNF10_HUMAN |
| Description: | tumor necrosis factor (ligand) superfamily, member 10 [Source:HGNC Symbol;Acc:11925] |
| Location: | chr3 q26.31 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T102 | EETIStVQEKQ | HPRD | |
| Y213 | QYIYKyTSYPD | PhosphoSitePlus | |
| T214 | YIYKYtSYPDP | PhosphoSitePlus | |
| S101 | SEETIsTVQEK | HPRD | |
| T135 | RGRSNtLSSPN | PhosphoSitePlus | |
| S225 | ILLMKsARNSC | PhosphoSitePlus | |
| S133 | GTRGRsNTLSS | PhosphoSitePlus | |
| Dephosphorylation site |
| TNF10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000241261 | D61N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000241261 | E252K | COSMIC | Melanoma | 21499247 | ENSP00000241261 | G180R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000241261 | E198K | COSMIC | Melanoma | 21499247 | ENSP00000241261 | I196K | COSMIC | Melanoma | 21499247 | ENSP00000241261 | Y185C | COSMIC | Lung Cancer | 20668451 | ENSP00000241261 | W231* | COSMIC | Melanoma |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000241261 | Uterine Cancer | Treatment (none vs. paclitaxel treatment) | cell line | Up | 20368835 | |
| Hyperphosphorylation site |
| TNF10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNF10_HUMAN | TR10B_HUMAN | ligand -> receptor | HPMR |
| TNF10_HUMAN | TR10C_HUMAN | ligand -> receptor | HPMR |
| TNF10_HUMAN | TR10A_HUMAN | ligand -> receptor | HPMR |
| TNF10_HUMAN | TR10D_HUMAN | ligand -> receptor | HPMR |
| TNF10_HUMAN | TR10A_HUMAN | other | KEGG |
| TNF10_HUMAN | TR10C_HUMAN | other | KEGG |
| TNF10_HUMAN | TR10D_HUMAN | other | KEGG |
| TNF10_HUMAN | TR11B_HUMAN | other | KEGG |
| TNF10_HUMAN | TR10B_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05164 | Influenza A |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05162 | Measles |
| hsa04210 | Apoptosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0006919 | activation of cysteine-type endopeptidase activity | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:2001238 | positive regulation of extrinsic apoptotic signali | IDA | biological_process |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IEP | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0043065 | positive regulation of apoptotic process | IDA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0090200 | positive regulation of release of cytochrome c fro | IDA | biological_process |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0043280 | positive regulation of cysteine-type endopeptidase | IDA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006917 | induction of apoptosis | TAS | biological_process |