Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLR4_HUMAN
Description:toll-like receptor 4 [Source:HGNC Symbol;Acc:11850]
Location:chr9 q33.1
Node attribute:PPI(target); PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S730EGFHKsRKVIVTIRPhosphoSitePlus
S530EGFHKsRKVIVHPRD
Y674RGENIyDAFVIPhosphoSitePlus
T175YFSNLtNLEHLLRR_4PhosphoSitePlus
Y551LQVLDySLNHIPhosphoSitePlus
S738VIVVVsQHFIQTIRPhosphoSitePlus
S790LYRLLsRNTYLTIRPhosphoSitePlus
S730EGFHKsRKVIVHPRD
Y680DAFVIySSQDETIRPhosphoSitePlus
S690EGFHKsRKVIVHPRD
S800LEWEDsVLGRHTIRPhosphoSitePlus

Dephosphorylation site
TLR4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363089Q505HCOSMICLung Cancer20668451
ENSP00000363089W26LCOSMICLung Cancer20668451
ENSP00000363089N282SCOSMICOvarian Cancer21720365
ENSP00000363089R745CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363089D299GOMIMColorectal Cancer16879199 17704786
ENSP00000363089L353FCOSMICMelanoma21499247
ENSP00000363089A291TBIOMARTBreast Cancer21930507, 21930502
ENSP00000363089C40FCOSMICOvarian Cancer21720365
ENSP00000377997A251TBIOMARTBreast Cancer21930507, 21930502
ENSP00000363089L138ICOSMICLung Cancer20668451
ENSP00000363089L795MCOSMICBreast Cancer20668451
ENSP00000363089T632NCOSMICLung Cancer20668451
ENSP00000363089S381CCOSMICLung Cancer20668451
ENSP00000363089P49SCOSMICSkin Cancer21984974
ENSP00000363089G830RCOSMICSkin Cancer21984974
ENSP00000363089T558NCOSMICHead and Neck Cancer21798893
ENSP00000363089P113TCOSMICLung Cancer20668451
ENSP00000377997R705CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363089L104FCOSMICSkin Cancer21984974
ENSP00000363089Q758HCOSMICLung Cancer20668451
ENSP00000363089E79QCOSMICLung Cancer20668451
ENSP00000363089G267ECOSMICLung Cancer20668451
ENSP00000363089Q163ECOSMICLung Cancer20668451
ENSP00000363089A814TCOSMICOvarian Cancer21720365
ENSP00000363089E79KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000363089V30MCOSMICHead and Neck Cancer21798893
ENSP00000363089T175NCOSMICHead and Neck Cancer21798893

Differential expressed protein
TLR4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLR4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD14_HUMANTLR4_HUMANotherKEGG
TLR4_HUMANMYD88_HUMANotherKEGG
TLR4_HUMANTCAM2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05164Influenza A
hsa05152Tuberculosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05130Pathogenic Escherichia coli infection
hsa05162Measles
hsa05323Rheumatoid arthritis
hsa05144Malaria
hsa05132Salmonella infection
hsa04145Phagosome
hsa04064NF-kappa B signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05133Pertussis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004888transmembrane signaling receptor activityNASmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0042742defense response to bacteriumTASbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0032729positive regulation of interferon-gamma productionISSbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0032689negative regulation of interferon-gamma productionISSbiological_process
GO:0032760positive regulation of tumor necrosis factor produISSbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0042346positive regulation of NF-kappaB import into nucleIDAbiological_process
GO:0045671negative regulation of osteoclast differentiationNASbiological_process
GO:0032700negative regulation of interleukin-17 productionISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051770positive regulation of nitric-oxide synthase biosyISSbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032497detection of lipopolysaccharideIDAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0032609interferon-gamma productionIEAbiological_process
GO:0045348positive regulation of MHC class II biosynthetic pIEAbiological_process
GO:0032728positive regulation of interferon-beta productionISSbiological_process
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0050671positive regulation of lymphocyte proliferationIEAbiological_process
GO:0032700negative regulation of interleukin-17 productionIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0000187activation of MAPK activityISSbiological_process
GO:0032722positive regulation of chemokine productionIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0071222cellular response to lipopolysaccharideISSbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyIEAbiological_process
GO:0016046detection of fungusNASbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0032733positive regulation of interleukin-10 productionISSbiological_process
GO:0045084positive regulation of interleukin-12 biosyntheticIDAbiological_process
GO:0046696lipopolysaccharide receptor complexIDAcellular_component
GO:0032707negative regulation of interleukin-23 productionISSbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0060729intestinal epithelial structure maintenanceIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0042088T-helper 1 type immune responseNASbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0032733positive regulation of interleukin-10 productionIEAbiological_process
GO:0032727positive regulation of interferon-alpha productionISSbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0032720negative regulation of tumor necrosis factor produISSbiological_process
GO:0010572positive regulation of platelet activationISSbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0050829defense response to Gram-negative bacteriumIEAbiological_process
GO:0032715negative regulation of interleukin-6 productionISSbiological_process
GO:0032728positive regulation of interferon-beta productionIEAbiological_process
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0032732positive regulation of interleukin-1 productionISSbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0045359positive regulation of interferon-beta biosynthetiIEAbiological_process
GO:0042535positive regulation of tumor necrosis factor biosyIDAbiological_process
GO:0070430positive regulation of nucleotide-binding oligomerIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0050829defense response to Gram-negative bacteriumICbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0032755positive regulation of interleukin-6 productionIDAbiological_process
GO:0032874positive regulation of stress-activated MAPK cascaIEAbiological_process
GO:0032727positive regulation of interferon-alpha productionIEAbiological_process
GO:0060729intestinal epithelial structure maintenanceISSbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0001530lipopolysaccharide bindingNASmolecular_function
GO:0032732positive regulation of interleukin-1 productionIEAbiological_process
GO:0032689negative regulation of interferon-gamma productionIEAbiological_process
GO:0032496response to lipopolysaccharideIDAbiological_process
GO:0042116macrophage activationIMPbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0071223cellular response to lipoteichoic acidIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionISSbiological_process
GO:0006955immune responseTASbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0032722positive regulation of chemokine productionIEAbiological_process
GO:0032707negative regulation of interleukin-23 productionIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0001875lipopolysaccharide receptor activityIDAmolecular_function
GO:0060907positive regulation of macrophage cytokine productIEAbiological_process
GO:0045416positive regulation of interleukin-8 biosynthetic IDAbiological_process
GO:0002537nitric oxide production involved in inflammatory rIEAbiological_process
GO:0010572positive regulation of platelet activationIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0070434positive regulation of nucleotide-binding oligomerIEAbiological_process
GO:0002218activation of innate immune responseIEAbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process