| UniProt/SwissProt ID: | T22D4_HUMAN |
| Description: | TSC22 domain family, member 4 [Source:HGNC Symbol;Acc:21696] |
| Location: | chr7 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S187 | EKPPLsASSPQ | HPRD | |
| S263 | LDSRPsSPALY | PhosphoSitePlus | |
| S370 | LRALAsPEQLA | TSC22 | PhosphoSitePlus; SysPTM |
| S165 | GPQARsFTGGL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S233 | RTPPLsRRKAV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S62 | TPRNGsPPPGA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S225 | AEAGGsGARTP | PhosphoSitePlus; HPRD; phosphoELM | |
| T167 | QARSFtGGLGQ | PhosphoSitePlus | |
| T211 | TSRAAtPLPSL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S279 | SLVHKsPDPFG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y268 | SSPALyFTHDA | HPRD; phosphoELM | |
| S116 | GIRGAsGGAGG | PhosphoSitePlus | |
| T157 | LRPPPtSPGPQ | HPRD | |
| T139 | GLGAPtPPSGL | PhosphoSitePlus; HPRD | |
| S177 | QLVVPsKAKAE | PhosphoSitePlus | |
| T270 | PALYFtHDASL | HPRD; phosphoELM | |
| S69 | PPGAPsSRFRV | HPRD | |
| S370 | LRALAsPEQLA | HPRD; phosphoELM; SysPTM | |
| S158 | RPPPTsPGPQA | PhosphoSitePlus; HPRD | |
| S70 | PGAPSsRFRVV | HPRD | |
| S132 | RLELAsLGLGA | HPRD | |
| T229 | GSGARtPPLSR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T57 | PGGKGtPRNGS | PhosphoSitePlus | |
| S49 | PNGEPsPDPGG | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| T22D4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000300181 | V329M | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| T22D4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| T22D4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | T22D4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCD_HUMAN | T22D4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | T22D4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | T22D4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| T22D4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006970 | response to osmotic stress | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |