Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNF1B_HUMAN
Description:HNF1 homeobox B [Source:HGNC Symbol;Acc:11630]
Location:chr17 q12
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S281RGVSPsKAHGLHomeoboxPhosphoSitePlus
S75AKGRLsGDEGSHNF-1_NPhosphoSitePlus
T88GDDYDtPPILKHNF-1_NPhosphoSitePlus
S363NEITSsSTISHHNF-1B_CPhosphoSitePlus
S288AHGLGsNLVTEHomeoboxPhosphoSitePlus
S538VVTDTsSISTLHNF-1B_CPhosphoSitePlus
S80SGDEGsEDGDDHNF-1_NPhosphoSitePlus

Dephosphorylation site
HNF1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225893G349*COSMICOvarian Cancer21720365
ENSP00000452674*532RCOSMICBreast Cancer20668451
ENSP00000225893W238*COSMICSkin Cancer21984974
ENSP00000225893I245TCOSMICOvarian Cancer21720365

Differential expressed protein
HNF1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HNF1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HNF1B_HUMANSUIS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
HNF1B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001822kidney developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048806genitalia developmentIMPbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0060429epithelium developmentIEAbiological_process
GO:0072095regulation of branch elongation involved in ureterIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0061017hepatoblast differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0035565regulation of pronephros sizeIMPbiological_process
GO:0060677ureteric bud elongationIEAbiological_process
GO:0039020pronephric nephron tubule developmentIGIbiological_process
GO:0001714endodermal cell fate specificationIEAbiological_process
GO:0072164mesonephric tubule developmentIEAbiological_process
GO:0072177mesonephric duct developmentIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0001822kidney developmentIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0030111regulation of Wnt receptor signaling pathwayIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0001826inner cell mass cell differentiationIEAbiological_process
GO:0060261positive regulation of transcription initiation frIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0072179nephric duct formationIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0050673epithelial cell proliferationIEAbiological_process
GO:0072181mesonephric duct formationIEAbiological_process
GO:0031018endocrine pancreas developmentIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0048793pronephros developmentIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0072176nephric duct developmentIEAbiological_process
GO:0030073insulin secretionIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0007492endoderm developmentIEAbiological_process
GO:0042663regulation of endodermal cell fate specificationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process