| UniProt/SwissProt ID: | STIP1_HUMAN |
| Description: | stress-induced-phosphoprotein 1 [Source:HGNC Symbol;Acc:11387] |
| Location: | chr11 q13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y354 | QERLAyINPDL | PhosphoSitePlus; HPRD; phosphoELM | |
| S16 | GNKALsVGNID | TPR_1 | PhosphoSitePlus; SysPTM |
| Y444 | EAMKDyTKAMD | TPR_1 | PhosphoSitePlus |
| T145 | DPRTRtLLSDP | PhosphoSitePlus | |
| T384 | AMKHYtEAIKR | MIT; TPR_1 | PhosphoSitePlus |
| Y275 | FEKGDyNKCRE | TPR_1 | PhosphoSitePlus |
| Y48 | NRSAAyAKKGD | TPR_2 | PhosphoSitePlus |
| S481 | YNRHDsPEDVK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y54 | AKKGDyQKAYE | TPR_2 | PhosphoSitePlus |
| Y58 | DYQKAyEDGCK | TPR_2 | PhosphoSitePlus |
| T198 | EEEIAtPPPPP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y476 | CMMAQyNRHDS | PhosphoSitePlus; HPRD; SysPTM | |
| Y269 | NQAAVyFEKGD | TPR_1 | PhosphoSitePlus |
| Y41 | HNHVLySNRSA | TPR_2 | PhosphoSitePlus |
| S16 | GNKALsVGNID | HPRD; phosphoELM; SysPTM | |
| Y383 | QAMKHyTEAIK | MIT; TPR_1 | PhosphoSitePlus |
| Dephosphorylation site |
| STIP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000305958 | R160* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000305958 | E192K | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000305958 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 3 | 15759316 | ENSP00000305958 | Leukemia | Normal vs. Cancer | cell line | Up | 3.5 | 17022645 | ENSP00000305958 | Leukemia | Normal vs. Cancer | cell line | Down | 0.36 | 17022645 | ENSP00000305958 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 2.4 | 17627933 | ENSP00000305958 | Melanoma | Treatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed) | cell line | Down | 0.59 | 17854218 | ENSP00000305958 | Breast Cancer | Normal vs. Cancer | tissue | Up | 4.2 | 20005186 | ENSP00000305958 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.45 | 20052998 | ENSP00000305958 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.1 | 20052998 | ENSP00000305958 | Breast Cancer | Metastasis | cell line | Up | 2.4 | 20052998 | ENSP00000305958 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.48 | 20739354 | ENSP00000305958 | Uterine Cancer | Normal vs. Cancer | cell line | Up | 2.6 | 15838902 | ENSP00000305958 | pancreatic ductal adenocarcinoma | Normal vs. Cancer | tissue | Down | 17492507 | ENSP00000305958 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 7 | 19199705 |
| Hyperphosphorylation site |
| STIP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M4K2_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK2_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A4_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| STIP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0030544 | Hsp70 protein binding | IEA | molecular_function |
| GO:0008022 | protein C-terminus binding | IEA | molecular_function |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0051087 | chaperone binding | IEA | molecular_function |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |