Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STIP1_HUMAN
Description:stress-induced-phosphoprotein 1 [Source:HGNC Symbol;Acc:11387]
Location:chr11 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y354QERLAyINPDLPhosphoSitePlus; HPRD; phosphoELM
S16GNKALsVGNIDTPR_1PhosphoSitePlus; SysPTM
Y444EAMKDyTKAMDTPR_1PhosphoSitePlus
T145DPRTRtLLSDPPhosphoSitePlus
T384AMKHYtEAIKRMIT; TPR_1PhosphoSitePlus
Y275FEKGDyNKCRETPR_1PhosphoSitePlus
Y48NRSAAyAKKGDTPR_2PhosphoSitePlus
S481YNRHDsPEDVKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y54AKKGDyQKAYETPR_2PhosphoSitePlus
Y58DYQKAyEDGCKTPR_2PhosphoSitePlus
T198EEEIAtPPPPPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y476CMMAQyNRHDSPhosphoSitePlus; HPRD; SysPTM
Y269NQAAVyFEKGDTPR_1PhosphoSitePlus
Y41HNHVLySNRSATPR_2PhosphoSitePlus
S16GNKALsVGNIDHPRD; phosphoELM; SysPTM
Y383QAMKHyTEAIKMIT; TPR_1PhosphoSitePlus

Dephosphorylation site
STIP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305958R160*TCGAOvarian Cancer21720365, 18772890
ENSP00000305958E192KBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000305958Hepatocellular CarcinomaNormal vs. CancertissueUp315759316
ENSP00000305958LeukemiaNormal vs. Cancercell lineUp3.517022645
ENSP00000305958LeukemiaNormal vs. Cancercell lineDown0.3617022645
ENSP00000305958Hepatocellular CarcinomaNormal vs. CancertissueUp2.417627933
ENSP00000305958MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.5917854218
ENSP00000305958Breast CancerNormal vs. CancertissueUp4.220005186
ENSP00000305958Breast CancerNormal vs. Cancercell lineDown0.4520052998
ENSP00000305958Breast CancerNormal vs. Cancercell lineUp1.120052998
ENSP00000305958Breast CancerMetastasiscell lineUp2.420052998
ENSP00000305958Breast CancerNormal vs. CancertissueUp0.4820739354
ENSP00000305958Uterine CancerNormal vs. Cancercell lineUp2.615838902
ENSP00000305958pancreatic ductal adenocarcinomaNormal vs. CancertissueDown17492507
ENSP00000305958Pancreatic CancerNormal vs. CancertissueUp719199705

Hyperphosphorylation site
STIP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K2_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
STIP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusTAScellular_component
GO:0030544Hsp70 protein bindingIEAmolecular_function
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005634nucleusTAScellular_component
GO:0051087chaperone bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0006950response to stressTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIPImolecular_function


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