| UniProt/SwissProt ID: | LOX15_HUMAN |
| Description: | arachidonate 15-lipoxygenase [Source:HGNC Symbol;Acc:433] |
| Location: | chr17 p13.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y613 | QHEEEyFSGPE | Lipoxygenase | PhosphoSitePlus |
| Y438 | GAFLTySSFCP | Lipoxygenase | PhosphoSitePlus |
| S591 | ASLQMsITWQL | Lipoxygenase | PhosphoSitePlus |
| S177 | VDFEVsLAKGL | Lipoxygenase | PhosphoSitePlus |
| Y158 | AGAKLyDLPVD | Lipoxygenase | PhosphoSitePlus |
| Dephosphorylation site |
| LOX15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000293761 | Q358* | COSMIC | Lung Cancer | ENSP00000293761 | G117C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000293761 | R500Q | COSMIC | Melanoma | ENSP00000293761 | *663G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000293761 | Q317* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| LOX15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LOX15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STAT6_HUMAN | LOX15_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| LOX15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0006629 | lipid metabolic process | NAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0050473 | arachidonate 15-lipoxygenase activity | IEA | molecular_function |
| GO:0006691 | leukotriene metabolic process | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0019370 | leukotriene biosynthetic process | IEA | biological_process |
| GO:0016165 | lipoxygenase activity | IEA | molecular_function |
| GO:0030282 | bone mineralization | IEA | biological_process |
| GO:0001503 | ossification | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0016702 | oxidoreductase activity, acting on single donors w | IEA | molecular_function |