Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SODC_HUMAN
Description:superoxide dismutase 1, soluble [Source:HGNC Symbol;Acc:11179]
Location:chr21 q22.11
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S103VSIEDsVISLSSod_CuPhosphoSitePlus
T59NTAGCtSAGPHSod_CuPhosphoSitePlus
T89DLGNVtADKDGSod_CuPhosphoSitePlus
T3___MAtKAVCVSod_CuPhosphoSitePlus
S106EDSVIsLSGDHSod_CuPhosphoSitePlus
S99GVADVsIEDSVHPRD; SysPTM
S99GVADVsIEDSVSod_CuPhosphoSitePlus; SysPTM
S60TAGCTsAGPHFSod_CuPhosphoSitePlus
S103VSIEDsVISLSHPRD
S35VKVWGsIKGLTSod_CuPhosphoSitePlus

Dephosphorylation site
SODC_HUMAN do not have dephosphorylation site.

Mutation site
SODC_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000270142Hepatocellular CarcinomaNormal vs. CancertissueDown0.2915759316
ENSP00000270142hepatitis B virusNormal vs. CancertissueDown0.414654528
ENSP00000270142hepatitis C virusNormal vs. CancertissueDown16762624
ENSP00000270142hepatitis B virusTreatment (none vs tetracycline-treatment)cell lineUp219671925
ENSP00000270142Lung CancerTreatment(none vs transfected with HPV-16 E7 gene)cell lineUp15684709
ENSP00000270142Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000270142Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000270142Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.1520804217
ENSP00000270142Breast CancerMetastasiscell lineDown0.3118582095
ENSP00000270142Breast CancerMetastasiscell lineUp5.718582095
ENSP00000270142breast ductal carcinomaNormal vs. CancertissueUp220534901
ENSP00000270142Breast CancerNormal vs. Cancercell lineDown0.7620543960
ENSP00000270142Breast CancerNormal vs. Cancercell lineDown0.6820543960
ENSP00000270142Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueUp2.520602252
ENSP00000270142Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.7416807943

Hyperphosphorylation site
SODC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANSODC_HUMANkinase -> substrateRobert H Newman (2013)
SODC_HUMANDERL1_HUMANotherKEGG
SODC_HUMANNFL_HUMANotherKEGG
SODC_HUMANCHP1_HUMANotherKEGG
SODC_HUMANBCL2_HUMANotherKEGG
SODC_HUMANTOM40_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05016Huntington's disease
hsa04146Peroxisome
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05020Prion diseases

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042803protein homodimerization activityNASmolecular_function
GO:0060088auditory receptor cell stereocilium organizationIEAbiological_process
GO:0008090retrograde axon cargo transportIEAbiological_process
GO:0001895retina homeostasisISSbiological_process
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0050665hydrogen peroxide biosynthetic processISSbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0060052neurofilament cytoskeleton organizationIEAbiological_process
GO:0060087relaxation of vascular smooth muscleISSbiological_process
GO:0007569cell agingIMPbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0006302double-strand break repairISSbiological_process
GO:0004784superoxide dismutase activityIDAmolecular_function
GO:0032839dendrite cytoplasmIDAcellular_component
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0000187activation of MAPK activityISSbiological_process
GO:0046716muscle cell homeostasisISSbiological_process
GO:0042493response to drugISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007566embryo implantationISSbiological_process
GO:0043025neuronal cell bodyIDAcellular_component
GO:0030346protein phosphatase 2B bindingIDAmolecular_function
GO:0006801superoxide metabolic processISSbiological_process
GO:0006749glutathione metabolic processIEAbiological_process
GO:0019430removal of superoxide radicalsIEAbiological_process
GO:0031667response to nutrient levelsIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0060087relaxation of vascular smooth muscleIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0051881regulation of mitochondrial membrane potentialIMPbiological_process
GO:0060088auditory receptor cell stereocilium organizationISSbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0060047heart contractionIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008090retrograde axon cargo transportISSbiological_process
GO:0042542response to hydrogen peroxideISSbiological_process
GO:0000302response to reactive oxygen speciesIEAbiological_process
GO:0001819positive regulation of cytokine productionIDAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0005507copper ion bindingIDAmolecular_function
GO:0004784superoxide dismutase activityIEAmolecular_function
GO:0043065positive regulation of apoptotic processICbiological_process
GO:0032287peripheral nervous system myelin maintenanceISSbiological_process
GO:0002262myeloid cell homeostasisIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0000303response to superoxideIDAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0009408response to heatISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0019430removal of superoxide radicalsISSbiological_process
GO:0046620regulation of organ growthNASbiological_process
GO:0006879cellular iron ion homeostasisISSbiological_process
GO:0005829cytosolIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0060047heart contractionIEAbiological_process
GO:0000303response to superoxideIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0045471response to ethanolISSbiological_process
GO:0008089anterograde axon cargo transportIEAbiological_process
GO:0007566embryo implantationIEAbiological_process
GO:0050665hydrogen peroxide biosynthetic processIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006801superoxide metabolic processIEAbiological_process
GO:0002262myeloid cell homeostasisISSbiological_process
GO:0008217regulation of blood pressureIEAbiological_process
GO:0033081regulation of T cell differentiation in thymusNASbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0005777peroxisomeISScellular_component
GO:0045859regulation of protein kinase activityIDAbiological_process
GO:0043085positive regulation of catalytic activityIDAbiological_process
GO:0005777peroxisomeIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0008217regulation of blood pressureISSbiological_process
GO:0019226transmission of nerve impulseIEAbiological_process
GO:0060052neurofilament cytoskeleton organizationISSbiological_process
GO:0006309apoptotic DNA fragmentationISSbiological_process
GO:0007626locomotory behaviorISSbiological_process
GO:0019226transmission of nerve impulseISSbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0001895retina homeostasisIEAbiological_process
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0045541negative regulation of cholesterol biosynthetic prIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048678response to axon injuryISSbiological_process
GO:0001890placenta developmentNASbiological_process
GO:0010033response to organic substanceIDAbiological_process
GO:0007605sensory perception of soundIEAbiological_process
GO:0008089anterograde axon cargo transportISSbiological_process
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0055114oxidation-reduction processIEAbiological_process
GO:0007283spermatogenesisISSbiological_process
GO:0007605sensory perception of soundISSbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0046688response to copper ionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0048538thymus developmentNASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0042554superoxide anion generationIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0032287peripheral nervous system myelin maintenanceIEAbiological_process
GO:0005759mitochondrial matrixNAScellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006749glutathione metabolic processISSbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0051087chaperone bindingIPImolecular_function
GO:0001541ovarian follicle developmentISSbiological_process
GO:0006309apoptotic DNA fragmentationIEAbiological_process