| UniProt/SwissProt ID: | TOM40_HUMAN |
| Description: | translocase of outer mitochondrial membrane 40 homolog (yeast) [Source:HGNC Symbol;Acc:18001] |
| Location: | chr19 q13.32 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y194 | QVDGEyRGSDF | Porin_3 | PhosphoSitePlus |
| T338 | PPLPLtLALGA | Porin_3 | PhosphoSitePlus |
| T338 | PPLPLtLALGA | HPRD | |
| Dephosphorylation site |
| TOM40_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000252487 | H112R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000410339 | H112R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385184 | H112R | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000252487 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 6.3 | 17655343 | ENSP00000252487 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 17655343 | ENSP00000252487 | Ovarian Cancer | Treatment (Paclitaxel-sensitive vs. Paclitaxel-resistant) | cell line | Down | 0.5 | 19714814 |
| Hyperphosphorylation site |
| TOM40_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SODC_HUMAN | TOM40_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008320 | protein transmembrane transporter activity | ISS | molecular_function |
| GO:0005741 | mitochondrial outer membrane | IEA | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005742 | mitochondrial outer membrane translocase complex | IDA | cellular_component |
| GO:0008308 | voltage-gated anion channel activity | IEA | molecular_function |
| GO:0031307 | integral to mitochondrial outer membrane | ISS | cellular_component |
| GO:0015288 | porin activity | IEA | molecular_function |
| GO:0055085 | transmembrane transport | IEA | biological_process |
| GO:0016021 | integral to membrane | IDA | cellular_component |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0006626 | protein targeting to mitochondrion | IMP | biological_process |
| GO:0046930 | pore complex | IEA | cellular_component |
| GO:0032592 | integral to mitochondrial membrane | IEA | cellular_component |