Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOM40_HUMAN
Description:translocase of outer mitochondrial membrane 40 homolog (yeast) [Source:HGNC Symbol;Acc:18001]
Location:chr19 q13.32
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y194QVDGEyRGSDFPorin_3PhosphoSitePlus
T338PPLPLtLALGAPorin_3PhosphoSitePlus
T338PPLPLtLALGAHPRD

Dephosphorylation site
TOM40_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000252487H112RBIOMARTBreast Cancer21930507, 21930502
ENSP00000410339H112RBIOMARTBreast Cancer21930507, 21930502
ENSP00000385184H112RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000252487acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp6.317655343
ENSP00000252487acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000252487Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.519714814

Hyperphosphorylation site
TOM40_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SODC_HUMANTOM40_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008320protein transmembrane transporter activityISSmolecular_function
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0005742mitochondrial outer membrane translocase complexIDAcellular_component
GO:0008308voltage-gated anion channel activityIEAmolecular_function
GO:0031307integral to mitochondrial outer membraneISScellular_component
GO:0015288porin activityIEAmolecular_function
GO:0055085transmembrane transportIEAbiological_process
GO:0016021integral to membraneIDAcellular_component
GO:0044267cellular protein metabolic processTASbiological_process
GO:0006626protein targeting to mitochondrionIMPbiological_process
GO:0046930pore complexIEAcellular_component
GO:0032592integral to mitochondrial membraneIEAcellular_component


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