| UniProt/SwissProt ID: | DERL1_HUMAN |
| Description: | derlin 1 [Source:HGNC Symbol;Acc:28454] |
| Location: | chr8 q24.13 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S201 | GRNFLsTPQFL | PhosphoSitePlus; HPRD | |
| S218 | RRGGVsGFGVP | PhosphoSitePlus | |
| Y190 | FLMFRyPMDLG | PhosphoSitePlus | |
| S226 | GVPPAsMRRAA | PhosphoSitePlus | |
| T202 | RNFLStPQFLY | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| DERL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384289 | S192N | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000259512 | S212N | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DERL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DERL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SODC_HUMAN | DERL1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030970 | retrograde protein transport, ER to cytosol | IMP | biological_process |
| GO:0019060 | intracellular transport of viral proteins in host | TAS | biological_process |
| GO:0045184 | establishment of protein localization | TAS | biological_process |
| GO:0030433 | ER-associated protein catabolic process | IDA | biological_process |
| GO:0005770 | late endosome | IEA | cellular_component |
| GO:0006986 | response to unfolded protein | IMP | biological_process |
| GO:0030968 | endoplasmic reticulum unfolded protein response | IDA | biological_process |
| GO:0004872 | receptor activity | NAS | molecular_function |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0034620 | cellular response to unfolded protein | IEA | biological_process |
| GO:0005769 | early endosome | IEA | cellular_component |
| GO:0042288 | MHC class I protein binding | IDA | molecular_function |
| GO:0016021 | integral to membrane | IDA | cellular_component |
| GO:0030176 | integral to endoplasmic reticulum membrane | IDA | cellular_component |