Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD6_HUMAN
Description:SMAD family member 6 [Source:HGNC Symbol;Acc:6772]
Location:chr15 q22.31
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S280PPPPYsRLSPRPhosphoSitePlus
S283PYSRLsPRDEYPhosphoSitePlus
S435VPPGYsIKVFDMH2PhosphoSitePlus
Y177LKTVTySLLKRMH1PhosphoSitePlus

Dephosphorylation site
SMAD6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000288840G471SCOSMICMelanoma21499247

Differential expressed protein
SMAD6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMAD6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MKNK2_HUMANSMAD6_HUMANkinase -> substrateRobert H Newman (2013)
SMAD6_HUMANSMAD2_HUMANotherKEGG
SMAD6_HUMANSMAD1_HUMANotherKEGG
IFNG_HUMANSMAD6_HUMANotherKEGG
TNFA_HUMANSMAD6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034713type I transforming growth factor beta receptor biIDAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0007352zygotic specification of dorsal/ventral axisIMPbiological_process
GO:0070410co-SMAD bindingIPImolecular_function
GO:0030509BMP signaling pathwayTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0030617transforming growth factor beta receptor, inhibitoIMPmolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0006955immune responseIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001657ureteric bud developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045750positive regulation of S phase of mitotic cell cycIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0034616response to laminar fluid shear stressIEPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0030514negative regulation of BMP signaling pathwayIDAbiological_process
GO:0030512negative regulation of transforming growth factor IMPbiological_process
GO:0060394negative regulation of pathway-restricted SMAD proIMPbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0010991negative regulation of SMAD protein complex assembIDAbiological_process
GO:0070698type I activin receptor bindingIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0031589cell-substrate adhesionIMPbiological_process
GO:0005515protein bindingIPImolecular_function