Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHC3_HUMAN
Description:SHC (Src homology 2 domain containing) transforming protein 3 [Source:HGNC Symbol;Acc:18181]
Location:chr9 q22.1
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S337EEGDGsDHPYYPhosphoSitePlus
Y341GSDHPyYNSIPPhosphoSitePlus
Y46PAAAPyLVSGEPhosphoSitePlus
Y308LRFKQyLQCPTPIDPhosphoSitePlus
S224QFAGMsISLTIPIDPhosphoSitePlus
S210PSKMLsSILGKPIDPhosphoSitePlus
Y406GSSDIySTPEGPhosphoSitePlus
Y424GEAPTyVNTQQPhosphoSitePlus
S407SSDIYsTPEGKPhosphoSitePlus
Y379GKEQTyYQGRHPhosphoSitePlus
Y342SDHPYyNSIPSPhosphoSitePlus

Dephosphorylation site
SHC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364995S407TBIOMARTBreast Cancer21930507, 21930502
ENSP00000364995P422TCOSMICLung Cancer20016488

Differential expressed protein
SHC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SHC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG10_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG12_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG5_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBB2_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBB3_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG13_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG3_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG2_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG8_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBB1_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBB5_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG11_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBG1_HUMANSHC3_HUMANGprotein -> effectorgpDB
FAK1_HUMANSHC3_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANSHC3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04910Insulin signaling pathway
hsa05034Alcoholism
hsa05100Bacterial invasion of epithelial cells
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04012ErbB signaling pathway
hsa05220Chronic myeloid leukemia
hsa05214Glioma
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0035249synaptic transmission, glutamatergicIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0035556intracellular signal transductionNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005575cellular_componentNDcellular_component


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