Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SF3B1_HUMAN
Description:splicing factor 3b, subunit 1, 155kDa [Source:HGNC Symbol;Acc:10768]
Location:chr2 q33.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T235LRWDEtPGRAKSF3b1PhosphoSitePlus
S190NGAAAsQPPSKHPRD
T261PTPSHtPAGAASF3b1PhosphoSitePlus
S229PGHTPsLRWDEHPRD
T354STPVLtPGKTPHPRD; phosphoELM; RegPhos
T303KTERDtPGHGSSF3b1PhosphoSitePlus
T1021LLPRLtPILKNHEAT_2PhosphoSitePlus
S129RTMIIsPERLDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T432PARKLtATPTPSF3b1PhosphoSitePlus
Y44YDQEIyGGSDSPhosphoSitePlus
T328IGETPtPGASKHPRD; phosphoELM; RegPhos
T354STPVLtPGKTPSF3b1PhosphoSitePlus
Y119DREDEyKKHRRPhosphoSitePlus
T125KKHRRtMIISPPhosphoSitePlus; HPRD
T299DETPKtERDTPHPRD; phosphoELM; RegPhos
T326DSIGEtPTPGASF3b1PhosphoSitePlus
S377PGHIMsMTPEQSF3b1PhosphoSitePlus
T248ETPGAtPGSKICDK2phosphoELM; RegPhos
T244AKGSEtPGATPSF3b1PhosphoSitePlus
Y1295DDKNTyIRYELPhosphoSitePlus
T227ETPGHtPSLRWHPRD; phosphoELM; RegPhos
Y38LDSTGyYDQEIPhosphoSitePlus
T316AETPRtDRGGDHPRD; phosphoELM; RegPhos
T442PLGGMtGFHMQHPRD
Y1136ALMNEyRVPELPhosphoSitePlus; HPRD
T142ADGGKtPDPKMPhosphoSitePlus; HPRD; RegPhos
S322DRGGDsIGETPSF3b1PhosphoSitePlus
T434RKLTAtPTPLGDYRK1AHPRD; RegPhos
T434RKLTAtPTPLGDYRK1BphosphoELM
S349SQMGGsTPVLTSF3b1PhosphoSitePlus
S332PTPGAsKRKSRSF3b1PhosphoSitePlus
Y421PPPAGyVPIRTSF3b1PhosphoSitePlus
S229PGHTPsLRWDESF3b1; SF3b1PhosphoSitePlus
T257KIWDPtPSHTPphosphoELM
T434RKLTAtPTPLGSF3b1PhosphoSitePlus
S308TPGHGsGWAETSF3b1PhosphoSitePlus
Y70DDDDDySSSTSPhosphoSitePlus
T207QTADQtPGATPHPRD; phosphoELM; RegPhos
S286HGGATsSARKNSF3b1; SF3b1PhosphoSitePlus
S190NGAAAsQPPSKSF3b1PhosphoSitePlus
T436LTATPtPLGGMSF3b1PhosphoSitePlus
T211QTPGAtPKKLSHPRD; phosphoELM; RegPhos
S217PKKLSsWDQAESF3b1PhosphoSitePlus
T278TPGHAtPGHGGHPRD
T223WDQAEtPGHTPHPRD; phosphoELM; RegPhos
S217PKKLSsWDQAEHPRD; phosphoELM; RegPhos
T296NRWDEtPKTERSF3b1PhosphoSitePlus
T267PAGAAtPGRGDHPRD; phosphoELM; RegPhos
S851AAEIIsRIVDDHPRD
S242GRAKGsETPGASF3b1PhosphoSitePlus
S259WDPTPsHTPAGSF3b1PhosphoSitePlus
T303KTERDtPGHGSHPRD; phosphoELM; RegPhos
T261PTPSHtPAGAAHPRD; phosphoELM
Y39DSTGYyDQEIYPhosphoSitePlus
S194ASQPPsKRKRRSF3b1PhosphoSitePlus
T313SGWAEtPRTDRCDK2phosphoELM; RegPhos
T432PARKLtATPTPHPRD; phosphoELM
T235LRWDEtPGRAKHPRD; phosphoELM; RegPhos
S400RNRPLsDEELDSF3b1PhosphoSitePlus
T313SGWAEtPRTDRSF3b1PhosphoSitePlus
T442PLGGMtGFHMQSF3b1PhosphoSitePlus
S332PTPGAsKRKSRHPRD; phosphoELM
S287GGATSsARKNRSF3b1PhosphoSitePlus
T61TSIAAtELEDDPhosphoSitePlus
T341SRWDEtPASQMSF3b1PhosphoSitePlus
Y152MNARTyMDVMRPhosphoSitePlus
S851AAEIIsRIVDDDUF4047PhosphoSitePlus
T244AKGSEtPGATPCDK2phosphoELM; RegPhos
T808ANYIKtEILPPPhosphoSitePlus
S194ASQPPsKRKRRHPRD; phosphoELM
T207QTADQtPGATPSF3b1PhosphoSitePlus
T369AMNMAtPTPGHSF3b1PhosphoSitePlus
T273PGRGDtPGHATHPRD; phosphoELM
T227ETPGHtPSLRWSF3b1PhosphoSitePlus
T313SGWAEtPRTDRHPRD; phosphoELM; RegPhos
T350QMGGStPVLTPHPRD; phosphoELM; RegPhos
T211QTPGAtPKKLSSF3b1PhosphoSitePlus
S322DRGGDsIGETPHPRD
T328IGETPtPGASKSF3b1PhosphoSitePlus
S488DESTLsPEEQKPhosphoSitePlus; HPRD; phosphoELM
S259WDPTPsHTPAGHPRD; phosphoELM
T608AAGLAtMISTMHPRD
T296NRWDEtPKTERHPRD; phosphoELM; RegPhos
Y84QKKPGyHAPVAPhosphoSitePlus
T248ETPGAtPGSKIHPRD; phosphoELM; RegPhos
S251GATPGsKIWDPSF3b1PhosphoSitePlus
S344DETPAsQMGGSSF3b1PhosphoSitePlus
T203RRWDQtADQTPHPRD
S308TPGHGsGWAETHPRD
T508KIKNGtPPMRKPhosphoSitePlus
Y1288HYPRIyNDDKNPhosphoSitePlus
S251GATPGsKIWDPHPRD
S349SQMGGsTPVLTHPRD; phosphoELM; RegPhos
T223WDQAEtPGHTPSF3b1PhosphoSitePlus
T273PGRGDtPGHATSF3b1PhosphoSitePlus
S344DETPAsQMGGSHPRD; phosphoELM; RegPhos
T426YVPIRtPARKLSF3b1PhosphoSitePlus
S216TPKKLsSWDQASF3b1PhosphoSitePlus
T299DETPKtERDTPSF3b1PhosphoSitePlus
T248ETPGAtPGSKISF3b1PhosphoSitePlus
T434RKLTAtPTPLGphosphoELM; RegPhos
Y101QSTEQyDPFAEPhosphoSitePlus
T244AKGSEtPGATPHPRD; phosphoELM; RegPhos
T436LTATPtPLGGMphosphoELM; RegPhos
S216TPKKLsSWDQAHPRD
T316AETPRtDRGGDSF3b1PhosphoSitePlus
T203RRWDQtADQTPSF3b1PhosphoSitePlus
T257KIWDPtPSHTPSF3b1PhosphoSitePlus
T267PAGAAtPGRGDSF3b1PhosphoSitePlus
S485VDVDEsTLSPEHPRD
T285GHGGAtSSARKSF3b1; SF3b1PhosphoSitePlus
S73DDYSSsTSLLGPhosphoSitePlus
T278TPGHAtPGHGGSF3b1PhosphoSitePlus
T326DSIGEtPTPGAHPRD; phosphoELM; RegPhos
T350QMGGStPVLTPSF3b1PhosphoSitePlus

Dephosphorylation site
SF3B1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000335321R625PBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000335321K182ECOSMICLymphoma21909114
ENSP00000335321Q699HCOSMICPancreatic Cancer
ENSP00000335321H662QCOSMICOther Cancer21998214
ENSP00000335321K700ECOSMICLymphoma21909114
ENSP00000335321E592KCOSMICOther Cancer21998214
ENSP00000335321G676DCOSMICOther Cancer21995386
ENSP00000335321I1241TCOSMICHead and Neck Cancer21798893
ENSP00000335321R625LCOSMICOther Cancer21998214
ENSP00000335321D781GCOSMICOther Cancer21995386
ENSP00000335321Y623CCOSMICLymphoma21909114
ENSP00000335321R630SCOSMICLymphoma22039264
ENSP00000335321P718LCOSMICMelanoma20016485
ENSP00000335321E622DCOSMICOther Cancer21998214
ENSP00000335321G740RCOSMICOther Cancer21995386
ENSP00000335321G347VCOSMICLymphoma21909114
ENSP00000335321N626DCOSMICLymphoma21909114
ENSP00000335321I704VCOSMICOther Cancer21995386
ENSP00000335321K666TCOSMICOther Cancer21998214
ENSP00000335321R590KCOSMICOther Cancer21995386
ENSP00000335321K666NBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000335321T663ICOSMICLymphoma22096241
ENSP00000335321I704NBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000335321V701FCOSMICOther Cancer21998214
ENSP00000335321E491GCOSMICOther Cancer21995386
ENSP00000335321Q670ECOSMICLymphoma22039264
ENSP00000335321I690FCOSMICTesticular Cancer21995386
ENSP00000335321N619KCOSMICLymphoma21995386
ENSP00000335321R1041HCOSMICRenal Cancer21995386
ENSP00000335321Q534PCOSMICBreast Cancer21995386
ENSP00000335321V701IBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000335321R568HCOSMICPancreatic Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000335321Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217

Hyperphosphorylation site
SF3B1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
DYR1A_HUMANSF3B1_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANSF3B1_HUMANkinase -> substrateRegPhos
MK10_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSF3B1_HUMANkinase -> substrateRegPhos
ARAF_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005689U12-type spliceosomal complexIDAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0005488bindingIEAmolecular_function
GO:0005681spliceosomal complexNAScellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0010467gene expressionTASbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000375RNA splicing, via transesterification reactionsNASbiological_process


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