| UniProt/SwissProt ID: | ADA12_HUMAN |
| Description: | ADAM metallopeptidase domain 12 [Source:HGNC Symbol;Acc:190] |
| Location: | chr10 q26.2 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T882 | PGQWEtGLRLA | PhosphoSitePlus | |
| Y907 | STHTAyIK | SRC | RegPhos |
| Dephosphorylation site |
| ADA12_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357668 | E208* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000357668 | D51G | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000357668 | G712E | COSMIC | Melanoma | 21618342 | ENSP00000357668 | G712E | COSMIC | Melanoma | 21618342 | ENSP00000357668 | D510N | COSMIC | Skin Cancer | 21984974 | ENSP00000357668 | P893S | COSMIC | Melanoma | 21618342 | ENSP00000357668 | A190T | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000357668 | D301H | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 16959974, 18241035, 16959974 18241035 | ENSP00000357668 | C411F | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000357668 | D510N | COSMIC | Skin Cancer | 21984974 | ENSP00000357668 | L792F | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421, 16959974, 18241035, 16959974 18241035 | ENSP00000357668 | G37R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000357668 | C411F | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000357668 | E208* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000357668 | G479E | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 16959974, 18241035, 16959974 18241035 | ENSP00000357668 | P893S | COSMIC | Melanoma | 21618342 |
| Differential expressed protein |
| ADA12_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADA12_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ADA12_HUMAN | SDC4_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| ADA12_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008237 | metallopeptidase activity | TAS | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0007520 | myoblast fusion | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |