| UniProt/SwissProt ID: | SDC4_HUMAN |
| Description: | syndecan 4 [Source:HGNC Symbol;Acc:10661] |
| Location: | chr20 q13.12 |
| Node attribute: | receptor; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y180 | KDEGSyDLGKK | Glycophorin_A; Syndecan; | PhosphoSitePlus |
| S179 | KKDEGsYDLGK | PRKCD | HPRD |
| S179 | KKDEGsYDLGK | PRKCA | HPRD |
| S179 | KKDEGsYDLGK | PKCa | RegPhos |
| S179 | KKDEGsYDLGK | PKCd | RegPhos |
| S179 | KKDEGsYDLGK | phosphoELM; RegPhos | |
| S179 | KKDEGsYDLGK | Glycophorin_A; Syndecan; | PhosphoSitePlus |
| T134 | VSMSStVQGSN | Glycophorin_A; Syndecan; | PhosphoSitePlus |
| Y197 | PTNEF | HPRD; phosphoELM; SysPTM | |
| Y197 | PTNEFyA____ | Herpes_gE | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| SDC4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SDC4_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361818 | Breast Cancer | Metastasis | cell line | Down | 18729497 | ENSP00000361818 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| SDC4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FGF2_HUMAN | SDC4_HUMAN | ligand -> receptor | HPMR |
| ADA12_HUMAN | SDC4_HUMAN | ligand -> receptor | HPMR |
| ZAGL2_HUMAN | SDC4_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | SDC4_HUMAN | kinase -> substrate | HPRD |
| KPCD_HUMAN | SDC4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04512 | ECM-receptor interaction |
| hsa05144 | Malaria |
| hsa04514 | Cell adhesion molecules (CAMs) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0045860 | positive regulation of protein kinase activity | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006027 | glycosaminoglycan catabolic process | TAS | biological_process |
| GO:0005925 | focal adhesion | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0043202 | lysosomal lumen | TAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006024 | glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0051894 | positive regulation of focal adhesion assembly | IEA | biological_process |
| GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0001968 | fibronectin binding | IEA | molecular_function |
| GO:0001657 | ureteric bud development | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0008092 | cytoskeletal protein binding | IEA | molecular_function |
| GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0051496 | positive regulation of stress fiber assembly | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005080 | protein kinase C binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0070053 | thrombospondin receptor activity | IMP | molecular_function |
| GO:0043034 | costamere | IEA | cellular_component |