Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTPRZ_HUMAN
Description:protein tyrosine phosphatase, receptor-type, Z polypeptide 1 [Source:HGNC Symbol;Acc:9685]
Location:chr7 q31.32
Node attribute:kinase; receptor; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1762INIVAyDHSRVY_phosphatasePhosphoSitePlus
Y1672QTAHFyLEDSTPhosphoSitePlus
Y2179ATQDDyVLEVRY_phosphatasePhosphoSitePlus
T2285LSLVStRQEENHPRD
S2055EKNRTsSIIPVY_phosphatasePhosphoSitePlus
T1421GEDGDtDDDGDPhosphoSitePlus
S2031QFQLLsQSNIQPhosphoSitePlus
Y2276QYQFLyKVILSY_phosphatasePhosphoSitePlus
T1668RKCFQtAHFYLPhosphoSitePlus
S2199PDSPIsKTFELY_phosphatasePhosphoSitePlus
Y1756KHKNRyINIVAY_phosphatasePhosphoSitePlus

Dephosphorylation site
PTPRZ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377047N468ICOSMICOvarian Cancer21720365
ENSP00000377047D1409YCOSMICHead and Neck Cancer21798893
ENSP00000377047S1512FCOSMICMelanoma21499247
ENSP00000377047S1204IBIOMARTBreast Cancer21930507, 21930502
ENSP00000377047D2178NCOSMICOvarian Cancer21720365
ENSP00000377047E1817fs*9COSMICOvarian Cancer21720365
ENSP00000377047I1783VCOSMICHead and Neck Cancer21798893
ENSP00000377047A1698VCOSMICOvarian Cancer21720365
ENSP00000377047E625KCOSMICSkin Cancer21984974
ENSP00000377047R469HBIOMARTBreast Cancer21930507, 21930502
ENSP00000377047S943FCOSMICSkin Cancer21984974

Differential expressed protein
PTPRZ_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTPRZ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTN_HUMANPTPRZ_HUMANligand -> receptorHPMR
PTPRZ_HUMANGIT1_HUMANkinase -> substrateKEGG
PTPRZ_HUMANRHG35_HUMANphosphatase -> substrateHPRD
PTPRZ_HUMANADDB_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneTAScellular_component
GO:0006470protein dephosphorylationTASbiological_process
GO:0008330protein tyrosine/threonine phosphatase activityNASmolecular_function
GO:0007409axonogenesisIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0072534perineuronal netIEAcellular_component
GO:0005001transmembrane receptor protein tyrosine phosphatasTASmolecular_function
GO:0007417central nervous system developmentTASbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0016311dephosphorylationIEAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component


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