Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RFA1_HUMAN
Description:replication protein A1, 70kDa [Source:HGNC Symbol;Acc:10289]
Location:chr17 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S177SLSHTsGGTQSPhosphoSitePlus
T191PIASLtPYQSKPhosphoSitePlus; HPRD
T164YGASKtFGKAAHPRD; SysPTM
Y461GDKPDyFSSVAPhosphoSitePlus
S135PAPAAsPAASSHPRD
S174AGPSLsHTSGGPhosphoSitePlus
Y599VKPVDyREYGRPhosphoSitePlus; HPRD
T590SRIKAtVMDVKPhosphoSitePlus; HPRD
T467FSSVAtVVYLRHPRD
S182SGGTQsKVVPIPhosphoSitePlus
S315NKSKDsLVDIIPhosphoSitePlus
S464PDYFSsVATVVHPRD
Y581VKVETyNDESRPhosphoSitePlus
S6MVGQLsEGAIARep-A_NPhosphoSitePlus
T180HTSGGtQSKVVPhosphoSitePlus; HPRD; phosphoELM
T35IRPITtGNSPPHPRD
S384KGARVsDFGGRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S463KPDYFsSVATVHPRD
S207RVTNKsQIRTWtRNA_antiPhosphoSitePlus
S6GAIAHPRD
Y470VATVVyLRKENPhosphoSitePlus; HPRD

Dephosphorylation site
RFA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254719E418fs*5COSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000254719Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
RFA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RFA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0005662DNA replication factor A complexIEAcellular_component
GO:0007126meiosisIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0032201telomere maintenance via semi-conservative replicaTASbiological_process
GO:0051276chromosome organizationIEAbiological_process
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0006289nucleotide-excision repairTASbiological_process
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0030097hemopoiesisIEAbiological_process
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006297nucleotide-excision repair, DNA gap fillingTASbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0000724double-strand break repair via homologous recombinIEAbiological_process
GO:0006310DNA recombinationTASbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000793condensed chromosomeIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0015629actin cytoskeletonIDAcellular_component
GO:0006261DNA-dependent DNA replicationTASbiological_process
GO:0000730DNA recombinase assemblyTASbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000723telomere maintenanceTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000722telomere maintenance via recombinationTASbiological_process
GO:0000800lateral elementIEAcellular_component
GO:0001673male germ cell nucleusIEAcellular_component
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process


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