Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RASA1_HUMAN
Description:RAS p21 protein activator (GTPase activating protein) 1 [Source:HGNC Symbol;Acc:9871]
Location:chr5 q14.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S827MESKQsCELSPHPRD
S650MESKQsCELSPHPRD
Y283DGKEIyNTIRREGFRHPRD
Y460DGKEIyNTIRREGFRHPRD; phosphoELM; RegPhos
T462KEIYNtIRRKTPhosphoSitePlus
T612PVKHFtNPYCNC2PhosphoSitePlus
Y615HFTNPyCNIYLC2PhosphoSitePlus
Y460DGKEIyNTIRRLCKHPRD; RegPhos
Y615HFTNPyCNIYLHPRD; phosphoELM; RegPhos
Y472TKDAFyKNIVKPhosphoSitePlus
Y438HFTNPyCNIYLHPRD
Y164LDGPEyEEEEVPhosphoSitePlus
Y283DGKEIyNTIRRLCKHPRD
S754RTLLAsILLRIPhosphoSitePlus
Y460DGKEIyNTIRRPDGFR_groupphosphoELM; RegPhos
Y460DGKEIyNTIRRPhosphoSitePlus
T453QVLNDtVDGKEPhosphoSitePlus
Y952GAKEPyMEGVNPhosphoSitePlus
Y239AMCGDyYIGGRSH2PhosphoSitePlus

Dephosphorylation site
RASA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000274376G700CTCGAOvarian Cancer21720365, 18772890
ENSP00000274376R589HCOSMICHead and Neck Cancer
ENSP00000274376F959LCOSMICHead and Neck Cancer21798893
ENSP00000274376K400GOMIMNeoplasms by Histologic Type8275088
ENSP00000274376R1016HCOSMICHead and Neck Cancer21798897
ENSP00000274376A806DCOSMICLung Cancer20668451
ENSP00000274376K400EHPINeoplasms by Histologic Type8275088
ENSP00000274376Q882*COSMICHead and Neck Cancer21798897
ENSP00000274376R398LOMIM, HPINeoplasms by Histologic Type8275088
ENSP00000274376I401VOMIM, HPINeoplasms by Histologic Type8275088
ENSP00000274376G700CCOSMICOvarian Cancer21720365

Differential expressed protein
RASA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RASA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMANRASA1_HUMANkinase -> substrateNetPath
ZAGL2_HUMANRASA1_HUMANkinase -> substrateRegPhos
EGFR_HUMANRASA1_HUMANkinase -> substrateHPRD; RegPhos
PGFRB_HUMANRASA1_HUMANkinase -> substrateRegPhos
LCK_HUMANRASA1_HUMANkinase -> substrateHPRD; RegPhos
RASA1_HUMANRRAS2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046580negative regulation of Ras protein signal transducIBAbiological_process
GO:0005099Ras GTPase activator activityIBAmolecular_function
GO:0019870potassium channel inhibitor activityNASmolecular_function
GO:0051020GTPase bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0032320positive regulation of Ras GTPase activityIBAbiological_process
GO:0001953negative regulation of cell-matrix adhesionIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0030833regulation of actin filament polymerizationIDAbiological_process
GO:0031235intrinsic to internal side of plasma membraneIBAcellular_component
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001726ruffleIEAcellular_component
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0001948glycoprotein bindingIPImolecular_function
GO:0051252regulation of RNA metabolic processNASbiological_process
GO:0008360regulation of cell shapeNASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007162negative regulation of cell adhesionIDAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0009790embryo developmentISSbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0005829cytosolTAScellular_component
GO:0007165signal transductionIDAbiological_process
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0000910cytokinesisISSbiological_process
GO:0001570vasculogenesisISSbiological_process
GO:0035556intracellular signal transductionNASbiological_process


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