| UniProt/SwissProt ID: | PTPRF_HUMAN |
| Description: | protein tyrosine phosphatase, receptor type, F [Source:HGNC Symbol;Acc:9670] |
| Location: | chr1 p34.2 |
| Node attribute: | phosphotase; substrate; receptor; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S709 | DEDVPsGPPRK | PhosphoSitePlus | |
| Y1676 | VNIMPyELTRV | Y_phosphatase | PhosphoSitePlus |
| Y1752 | EKCHQyWPAER | Y_phosphatase | PhosphoSitePlus |
| Y1410 | YINANyIDGYR | Y_phosphatase | PhosphoSitePlus |
| Y205 | SDQGKyECVAT | HPRD | |
| S1027 | AAMKTsVLLSW | fn3 | PhosphoSitePlus |
| Y1888 | QTEDQyQLCYR | Y_phosphatase | PhosphoSitePlus |
| Y450 | RGYRVyYTPDS | fn3 | PhosphoSitePlus |
| T816 | PKIVTtTGAVP | PhosphoSitePlus | |
| Y1852 | LERMRyEGVVD | FYN | HPRD |
| T215 | TNSAGtRYSAP | HPRD | |
| T594 | GVGVFtPTIEA | PhosphoSitePlus | |
| Y205 | SDQGKyECVAT | I-set | PhosphoSitePlus |
| Y1381 | KPKNRyANVIA | Y_phosphatase | PhosphoSitePlus |
| T452 | YRVYYtPDSRR | fn3 | PhosphoSitePlus |
| T596 | GVFTPtIEART | PhosphoSitePlus | |
| S1390 | IAYDHsRVILT | Y_phosphatase | PhosphoSitePlus |
| T825 | VPGRPtMMIST | PhosphoSitePlus | |
| Y1387 | ANVIAyDHSRV | Y_phosphatase | PhosphoSitePlus |
| Y1861 | LERMRyEGVVD | FYN | HPRD |
| S1031 | TSVLLsWEVPD | fn3 | PhosphoSitePlus |
| S455 | YYTPDsRRPPN | fn3 | PhosphoSitePlus |
| Y1898 | RAALEyLGSFD | PhosphoSitePlus | |
| T1323 | RLNYQtPGMRD | PhosphoSitePlus | |
| T817 | KIVTTtGAVPG | PhosphoSitePlus | |
| Y1321 | MRRLNyQTPGM | PhosphoSitePlus | |
| Y224 | APANLyVRVRR | PhosphoSitePlus; HPRD | |
| T1026 | AAAMKtSVLLS | fn3 | PhosphoSitePlus |
| Y451 | GYRVYyTPDSR | fn3 | PhosphoSitePlus |
| Y1905 | GSFDHyAT___ | PhosphoSitePlus | |
| S394 | VLAVNsIGRGP | fn3 | PhosphoSitePlus |
| Y1892 | QYQLCyRAALE | Y_phosphatase | PhosphoSitePlus |
| Y1777 | YNMPQyILREF | Y_phosphatase | PhosphoSitePlus |
| Y1356 | KFSQEyESIDP | PhosphoSitePlus | |
| Y1621 | PARNLyAHIQK | PhosphoSitePlus | |
| T703 | PVLVRtDEDVP | PhosphoSitePlus | |
| Y217 | SAGTRySAPAN | HPRD | |
| Y1694 | VEGSDyINASF | Y_phosphatase | PhosphoSitePlus |
| Y296 | VRSANyTCVAI | I-set | PhosphoSitePlus |
| Dephosphorylation site |
| PTPRF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361491 | W683* | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000353030 | K1650N | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000398822 | L1205V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353030 | R216H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361490 | L1205V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353030 | A1659T | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000353030 | L1214V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361491 | L1214V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353030 | N896K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361491 | N896K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353030 | V733F | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000361491 | R216H | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361491 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | |
| Hyperphosphorylation site |
| PTPRF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NID1_HUMAN | PTPRF_HUMAN | ligand -> receptor | HPMR |
| FYN_HUMAN | PTPRF_HUMAN | kinase -> substrate | HPRD |
| PTPRF_HUMAN | IRS1_HUMAN | phosphatase -> substrate | KEGG |
| PTPRF_HUMAN | INSR_HUMAN | phosphatase -> substrate | KEGG |
| PTPRF_HUMAN | SHC2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04910 | Insulin signaling pathway |
| hsa04520 | Adherens junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatas | TAS | biological_process |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IDA | molecular_function |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |